N-(4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)ethanesulfonamide

Base Information

Chemical Name:N-(4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)ethanesulfonamide
CAS No.:1428764-97-9
Molecular Formula:C₂₄H₂₅F₃N₄O₃S
Molecular Weight:506.549
Hs Code.:

Synonyms:N-(4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)ethanesulfonamide

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Chemical Property of N-(4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)ethanesulfonamide

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Technology Process of N-(4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)ethanesulfonamide

There total 12 articles about N-(4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1428765-32-5
(2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methanamine

: 1428765-43-8
phenyl 4-(ethylsulfonamidomethyl)phenylcarbamate

: 1428764-97-9
N-(4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)ethanesulfonamide

Guidance literature:: With dmap; In acetonitrile; at 20 - 50 ℃; for 15h;

Reference yield:

: 386704-06-9
2-chloro-6-(trifluoromethyl)nicotinonitrile

: 1428764-97-9
N-(4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; water; ethanol / 2 h / 100 °C / 5250.53 Torr / Inert atmosphere; Microwave irradiation

2: ammonia; hydrogen / methanol / 80 °C / 7500.75 Torr

3: dmap / acetonitrile / 15 h / 20 - 50 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; hydrogen; sodium carbonate; In methanol; ethanol; water; toluene; acetonitrile;

Reference yield:

: 17933-03-8
m-tolylboronic acid

: 1428764-97-9
N-(4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; water; ethanol / 2 h / 100 °C / 5250.53 Torr / Inert atmosphere; Microwave irradiation

2: ammonia; hydrogen / methanol / 80 °C / 7500.75 Torr

3: dmap / acetonitrile / 15 h / 20 - 50 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; hydrogen; sodium carbonate; In methanol; ethanol; water; toluene; acetonitrile;