1-[6-(Tetrahydro-pyran-2-yloxy)-hexyl]-cyclohexanecarboxylic acid methyl ester

Base Information

• Chemical Name: 1-[6-(Tetrahydro-pyran-2-yloxy)-hexyl]-cyclohexanecarboxylic acid methyl ester
• CAS No.: 75266-85-2
• Molecular Formula: C₁₉H₃₄O₄
• Molecular Weight: 326.477
• Mol file: 75266-85-2.mol

Synonyms:1-[6-(Tetrahydro-pyran-2-yloxy)-hexyl]-cyclohexanecarboxylic acid methyl ester

Chemical Property of 1-[6-(Tetrahydro-pyran-2-yloxy)-hexyl]-cyclohexanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-[6-(Tetrahydro-pyran-2-yloxy)-hexyl]-cyclohexanecarboxylic acid methyl ester

There total 1 articles about 1-[6-(Tetrahydro-pyran-2-yloxy)-hexyl]-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-iodohexanol, tetrahydropyranyl ether (65785-44-6) + methyl cyclohexylcarboxylate (4630-82-4) → 1-[6-(Tetrahydro-pyran-2-yloxy)-hexyl]-cyclohexanecarboxylic acid methyl ester (75266-85-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine; Yield given. Multistep reaction; 1) THF, 0 deg C, 15 min; -70 deg C, 30 min, 2) -70 deg C, 10 min; 25 deg C, 50 min;

DOI:10.1021/jo01313a014

Reference yield: 55.0%

1-[6-(Tetrahydro-pyran-2-yloxy)-hexyl]-cyclohexanecarboxylic acid methyl ester (75266-85-2) → 1-(6-tetrahydropyranyloxyhexyl)-1-hydroxymethylcyclohexane (67838-05-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 0.25h; Heating;

DOI:10.1021/jo01313a014

Reference yield:

1-[6-(Tetrahydro-pyran-2-yloxy)-hexyl]-cyclohexanecarboxylic acid methyl ester (75266-85-2) → 6-[1-(3-hydroxy-1-octenyl)cyclohexyl]hexanoic acid (67838-33-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 55 percent / LiAlH₄ / diethyl ether / 0.25 h / Heating

2: CrO₃ / pyridine

3: dimethylsulfoxide; 1,2-dimethoxy-ethane / 24 h / Heating

4: NaBH₄ / methanol

6: base / methanol

With chromium(VI) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; In pyridine; methanol; 1,2-dimethoxyethane; diethyl ether; dimethyl sulfoxide;

DOI:10.1021/jo01313a014

upstream raw materials:

6-iodohexanol, tetrahydropyranyl ether

methyl cyclohexylcarboxylate

Downstream raw materials:

1-(6-tetrahydropyranyloxyhexyl)-1-hydroxymethylcyclohexane

6-[1-(3-hydroxy-1-octenyl)cyclohexyl]hexanoic acid

(E)-1-{1-[6-(Tetrahydro-pyran-2-yloxy)-hexyl]-cyclohexyl}-oct-1-en-3-ol

(E)-1-{1-[6-(Tetrahydro-pyran-2-yloxy)-hexyl]-cyclohexyl}-oct-1-en-3-one