((piperazine-1,4-diylbis(methylene))bis(4-fluoro-2,1-phenylene))diboronic acid

Base Information

• Chemical Name: ((piperazine-1,4-diylbis(methylene))bis(4-fluoro-2,1-phenylene))diboronic acid
• CAS No.: 1455493-41-0
• Molecular Formula: C₁₈H₂₂B₂F₂N₂O₄
• Molecular Weight: 390.002
• Mol file: 1455493-41-0.mol

Synonyms:((piperazine-1,4-diylbis(methylene))bis(4-fluoro-2,1-phenylene))diboronic acid

Chemical Property of ((piperazine-1,4-diylbis(methylene))bis(4-fluoro-2,1-phenylene))diboronic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((piperazine-1,4-diylbis(methylene))bis(4-fluoro-2,1-phenylene))diboronic acid

There total 3 articles about ((piperazine-1,4-diylbis(methylene))bis(4-fluoro-2,1-phenylene))diboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

piperazine (110-85-0) + (4-fluoro-2-formylphenyl)boronic acid (825644-26-6) → ((piperazine-1,4-diylbis(methylene))bis(4-fluoro-2,1-phenylene))diboronic acid (1455493-41-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at -10 ℃; for 0.75h;

DOI:10.1016/j.tet.2013.07.102

Reference yield: 45.0%

3,3'-(piperazine-1,4-diyl)bis(5-fluorobenzo[c][1,2]oxaborol-1(3H)-ol) → ((piperazine-1,4-diylbis(methylene))bis(4-fluoro-2,1-phenylene))diboronic acid (1455493-41-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃;

DOI:10.1016/j.tet.2013.07.102

Reference yield:

(4-fluoro-2-formylphenyl)boronic acid (825644-26-6) → ((piperazine-1,4-diylbis(methylene))bis(4-fluoro-2,1-phenylene))diboronic acid (1455493-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 24 h / 20 °C

2: sodium tetrahydroborate / methanol / 20 °C

With sodium tetrahydroborate; In methanol; diethyl ether;

DOI:10.1016/j.tet.2013.07.102

upstream raw materials:

(4-fluoro-2-formylphenyl)boronic acid

piperazine