(2R,4S,5S)-5-amino-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

Base Information

• Chemical Name: (2R,4S,5S)-5-amino-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide
• CAS No.: 1067648-57-0
• Molecular Formula: C₂₅H₃₃F₂N₃O₄
• Molecular Weight: 477.552

Synonyms:(2R,4S,5S)-5-amino-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

Chemical Property of (2R,4S,5S)-5-amino-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4S,5S)-5-amino-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

There total 5 articles about (2R,4S,5S)-5-amino-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(2R,4S,5S)-5-azido-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide (1067648-56-9) → (2R,4S,5S)-5-amino-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide (1067648-57-0)

Guidance literature:

With water; triphenylphosphine; In methanol; at 20 ℃;

DOI:10.1016/j.ejmech.2009.11.013

Reference yield: 82.0%

→ (2R,4S,5S)-5-amino-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide (1067648-57-0)

Guidance literature:

Reference yield:

L-valine benzylamide (106566-02-3,120369-25-7,144902-31-8) → (2R,4S,5S)-5-amino-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide (1067648-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 96 h / Reflux

2: water; triphenylphosphine / methanol / 20 °C

With 2-hydroxypyridin; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol;

DOI:10.1016/j.ejmech.2009.11.013

upstream raw materials:

(2R,4S,5S)-5-azido-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

C₁₃H₁₄F₂O₄

5,6-anhydro-2,3-dideoxy-2-methyl-D-glucono-1,4-lactone

L-valine benzylamide

Downstream raw materials:

N-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difiuorophenoxymethyl)-2-hydroxy-pentyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1067648-57-0 (2R,4S,5S)-5-amino-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send