2-<(2R,3S,4S)-1-benzyl-4-<(tert-butoxycarbonyl)amino>-3-(tert-butyldimethylsiloxy)-5-phenylpentyl>-5-acetylimidazole

Base Information

Chemical Name:2-<(2R,3S,4S)-1-benzyl-4-<(tert-butoxycarbonyl)amino>-3-(tert-butyldimethylsiloxy)-5-phenylpentyl>-5-acetylimidazole
CAS No.:150349-08-9
Molecular Formula:C₃₄H₄₉N₃O₄Si
Molecular Weight:591.866
Hs Code.:

Synonyms:2-<(2R,3S,4S)-1-benzyl-4-<(tert-butoxycarbonyl)amino>-3-(tert-butyldimethylsiloxy)-5-phenylpentyl>-5-acetylimidazole

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Chemical Property of 2-<(2R,3S,4S)-1-benzyl-4-<(tert-butoxycarbonyl)amino>-3-(tert-butyldimethylsiloxy)-5-phenylpentyl>-5-acetylimidazole

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Technology Process of 2-<(2R,3S,4S)-1-benzyl-4-<(tert-butoxycarbonyl)amino>-3-(tert-butyldimethylsiloxy)-5-phenylpentyl>-5-acetylimidazole

There total 2 articles about 2-<(2R,3S,4S)-1-benzyl-4-<(tert-butoxycarbonyl)amino>-3-(tert-butyldimethylsiloxy)-5-phenylpentyl>-5-acetylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98818-51-0
N-(1,1-dimethylethoxycarbonyl)-5(S)-amino-4(S)-(t-butyldimethylsilyloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoic acid

: 150349-08-9
2-<(2R,3S,4S)-1-benzyl-4-<(tert-butoxycarbonyl)amino>-3-(tert-butyldimethylsiloxy)-5-phenylpentyl>-5-acetylimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / 1-hydroxybenzotriazole, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 24 h / Ambient temperature

2: 1.) H₂, 2.) NaOH / 1.) 10percent Pd/C / 1.) EtOH, 5 h, 2.) EtOH, reflux, overnight

With sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1021/jm00045a015

Reference yield:

: 149976-33-0
[(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-(5-methyl-isoxazol-4-ylcarbamoyl)-5-phenyl-pentyl]-carbamic acid tert-butyl ester

: 150349-08-9
2-<(2R,3S,4S)-1-benzyl-4-<(tert-butoxycarbonyl)amino>-3-(tert-butyldimethylsiloxy)-5-phenylpentyl>-5-acetylimidazole

Guidance literature:: With sodium hydroxide; hydrogen; palladium on activated charcoal; Multistep reaction; 1.) EtOH, 5 h, 2.) EtOH, reflux, overnight;
DOI:10.1021/jm00045a015