3,5-Dimethoxy-2-methylbenzoic acid

Base Information

• Chemical Name: 3,5-Dimethoxy-2-methylbenzoic acid
• CAS No.: 50423-23-9
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.203
• European Community (EC) Number: 898-392-9
• Mol file: 50423-23-9.mol

Synonyms:3,5-dimethoxy-2-methylbenzoic acid;3,5-dimethoxy-2-methyl-benzoic acid;SCHEMBL1651653;WMPVKMPRBLTWIN-UHFFFAOYSA-N;50423-23-9;DB-293947

Chemical Property of 3,5-Dimethoxy-2-methylbenzoic acid

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 196.07355886
• Heavy Atom Count: 14
• Complexity: 204

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C=C(C=C1OC)OC)C(=O)O

Technology Process of 3,5-Dimethoxy-2-methylbenzoic acid

There total 7 articles about 3,5-Dimethoxy-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3,5-dimethoxy-2-methylbenzoate (52344-94-2) → 3,5-dimethoxy-2-methyl-benzoic acid (50423-23-9)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In methanol;

Reference yield:

1-ethyl-3,5-dimethoxy-2-methyl-benzene → 3,5-dimethoxy-2-methyl-benzoic acid (50423-23-9) + 2-ethyl-4,6-dimethoxy-benzoic acid (75996-28-0)

Guidance literature:

With alkaline aqueous permanganate solution;

Reference yield:

ortho-methylbenzoic acid (118-90-1) → 3,5-dimethoxy-2-methyl-benzoic acid (50423-23-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; SO₃ / 160 - 170 °C

2: durch Kalischmelze

With sulfuric acid; sulfur trioxide;

upstream raw materials:

3,5-dihydroxy-2-methylbenzoic acid

dimethyl sulfate

ortho-methylbenzoic acid

2-methyl-3,5-disulfo-benzoic acid

Downstream raw materials:

1-(3,5-dimethoxy-2-methyl-phenyl)-ethanone

3,5-dimethoxy-2-methyl-benzoic acid amide

(3,5-dimethoxy-2-methyl-phenyl)-acetic acid amide

1-sec-butyl-2-methyl-3,5-bis-(4-nitro-benzoyloxy)-benzene