Technology Process of 2-O-benzyl-<8-methyl-2,3,4,4a,8,9-hexahydro-(4aS,6Z,8S,9aR)-pyrano<3,2-b>oxepan-6-yl>ethanol
There total 10 articles about 2-O-benzyl-<8-methyl-2,3,4,4a,8,9-hexahydro-(4aS,6Z,8S,9aR)-pyrano<3,2-b>oxepan-6-yl>ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / H2 / 10percent Pd/C / 0.5 h
2: 61 percent / Lawesson's reagent / toluene / 12 h / Heating
With
Lawessons reagent; hydrogen;
palladium on activated charcoal;
In
toluene;
DOI:10.1021/ja00173a013
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 88 percent / ZnBr2 / diethyl ether / 0.33 h / -78 °C
2: 100 percent / H2 / Pd(OH)2 / methanol / 3 h / 25 °C
3: 1.) Ph3P, dipyridyl disulfide, 2.) AgClO4 / 1.) THF, 25 deg C, 30 min, 2.) benzene, 80 deg C, 1 h
4: HF*pyridine / tetrahydrofuran / 2 h / Ambient temperature
5: NEt3, methanesulfonyl chloride, DBU / benzene; CH2Cl2 / 1 h / 45 °C
6: 95 percent / H2 / 10percent Pd/C / 0.5 h
7: 61 percent / Lawesson's reagent / toluene / 12 h / Heating
With
Lawessons reagent; 2,2'-dipyridyldisulphide; hydrogen; silver perchlorate; pyridine hydrogenfluoride; methanesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; zinc dibromide;
palladium dihydroxide; palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; benzene;
DOI:10.1021/ja00173a013
- Guidance literature:
-
Multi-step reaction with 9 steps
1: oxalyl chloride, DMSO / CH2Cl2 / 0.75 h / -78 °C
2: 88 percent / ZnBr2 / diethyl ether / 0.33 h / -78 °C
3: 100 percent / H2 / Pd(OH)2 / methanol / 3 h / 25 °C
4: 1.) Ph3P, dipyridyl disulfide, 2.) AgClO4 / 1.) THF, 25 deg C, 30 min, 2.) benzene, 80 deg C, 1 h
5: HF*pyridine / tetrahydrofuran / 2 h / Ambient temperature
6: NEt3, methanesulfonyl chloride, DBU / benzene; CH2Cl2 / 1 h / 45 °C
7: 95 percent / H2 / 10percent Pd/C / 0.5 h
8: 61 percent / Lawesson's reagent / toluene / 12 h / Heating
With
Lawessons reagent; oxalyl dichloride; 2,2'-dipyridyldisulphide; hydrogen; silver perchlorate; pyridine hydrogenfluoride; dimethyl sulfoxide; methanesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; zinc dibromide;
palladium dihydroxide; palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; benzene;
DOI:10.1021/ja00173a013
