5-Hydroxymethyl-isophthalic acid bis-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

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Chemical Name:5-Hydroxymethyl-isophthalic acid bis-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester
CAS No.:193953-27-4
Molecular Formula:C₃₉H₄₄O₁₃
Molecular Weight:720.771
Hs Code.:

Synonyms:5-Hydroxymethyl-isophthalic acid bis-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

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Chemical Property of 5-Hydroxymethyl-isophthalic acid bis-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

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Technology Process of 5-Hydroxymethyl-isophthalic acid bis-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

There total 6 articles about 5-Hydroxymethyl-isophthalic acid bis-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

: 5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid bis-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester; compound with 2,2,2-trifluoro-ethanol

: 193953-27-4
5-Hydroxymethyl-isophthalic acid bis-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

Guidance literature:: With pyridine hydrogenfluoride; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1002/hlca.19970800402

Reference yield:

: 2672-58-4
1,3,5-tris-(methoxycarbonyl)benzene

: 193953-27-4
5-Hydroxymethyl-isophthalic acid bis-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

Guidance literature:: Multi-step reaction with 6 steps

1: 20.1 percent / LiAlH₄ / tetrahydrofuran / 0.17 h / 1 - 30 °C

2: 92.8 percent / DMAP / dimethylformamide / 24 h / Ambient temperature

3: 78 percent / LiOH / methanol; dioxane; H₂O / 0.5 h

4: (COCl)2 / dimethylformamide / 14 h

5: pyridine, (t-Bu)Ph₂SiF / CH₂Cl₂ / 0 deg C, 3 h, RT, 8 h

6: 92.5 percent / HF*pyridine / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; dmap; lithium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; tert-butyl diphenylfluorosilane; pyridine hydrogenfluoride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800402

Reference yield:

: 109862-53-5
dimethyl 5-hydroxymethylbenzene-1,3-dicarboxylate

: 193953-27-4
5-Hydroxymethyl-isophthalic acid bis-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: 92.8 percent / DMAP / dimethylformamide / 24 h / Ambient temperature

2: 78 percent / LiOH / methanol; dioxane; H₂O / 0.5 h

3: (COCl)2 / dimethylformamide / 14 h

4: pyridine, (t-Bu)Ph₂SiF / CH₂Cl₂ / 0 deg C, 3 h, RT, 8 h

5: 92.5 percent / HF*pyridine / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; dmap; lithium hydroxide; oxalyl dichloride; tert-butyl diphenylfluorosilane; pyridine hydrogenfluoride; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800402