3-Methyl-6-(2-methylpropylidene)piperazine-2,5-dione

Base Information

Chemical Name:3-Methyl-6-(2-methylpropylidene)piperazine-2,5-dione
CAS No.:286838-85-5
Molecular Formula:C₉H₁₄N₂O₂
Molecular Weight:182.222
Hs Code.:
DSSTox Substance ID:DTXSID20699511
Mol file:286838-85-5.mol

Synonyms:3-methyl-6-(2-methylpropylidene)piperazine-2,5-dione;286838-85-5;DTXSID20699511

Suppliers and Price of 3-Methyl-6-(2-methylpropylidene)piperazine-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-Methyl-6-(2-methylpropylidene)piperazine-2,5-dione

Chemical Property:

PSA：58.20000
LogP:0.81840
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:182.105527694
Heavy Atom Count:13
Complexity:269

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(=O)NC(=CC(C)C)C(=O)N1

Technology Process of 3-Methyl-6-(2-methylpropylidene)piperazine-2,5-dione

There total 13 articles about 3-Methyl-6-(2-methylpropylidene)piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 286838-93-5
(S)-1-acetyl-3-[(Z)-isobutylidene]-6-methyl-2,5-piperazinedione

: 75557-42-5,286838-85-5
(S)-3-[(Z)-isobutylidene]-6-methyl-2,5-piperazinedione

Guidance literature:: With hydrazine hydrate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1002/(sici)1099-0690(200005)2000:10<1993::aid-ejoc1993>3.0.co;2-i

Reference yield: 86.0%

: 286838-94-6
(S)-1-acetyl-3-[(E)-isobutylidene]-6-methyl-2,5-piperazinedione

: 75557-47-0,286838-85-5
(6S)-3-[(E)-isobutylidene]-6-methyl-2,5-piperazinedione

Guidance literature:: With hydrazine hydrate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1002/(sici)1099-0690(200005)2000:10<1993::aid-ejoc1993>3.0.co;2-i

Reference yield:

: 4526-77-6
(S)-3-methyl-2,5-piperazinedione

: 286838-85-5
(3R/S)-3-methyl-6-[(Z)-2-methylpropylidene]-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 3.30 g / acetic acid / 7 h / 130 °C

2: 24 percent / tBuOK / 2-methyl-propan-2-ol; dimethylformamide / 6 h / 0 - 20 °C

3: 86 percent / hydrazine hydrate / dimethylformamide / 3 h / 20 °C

4: 95 percent Spectr_. / aq. HBr / dioxane / 3 h / Heating

With potassium tert-butylate; hydrogen bromide; hydrazine hydrate; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Acetylation / 2: Condensation / 3: Deacetylation / 4: Rearrangement;
DOI:10.1002/(sici)1099-0690(200005)2000:10<1993::aid-ejoc1993>3.0.co;2-i