4'-N-ε-Boc-lysyl)>primaquine

Base Information

• Chemical Name: 4'-N-ε-Boc-lysyl)>primaquine
• CAS No.: 112925-76-5
• Molecular Formula: C₄₃H₆₃N₇O₈
• Molecular Weight: 806.015
• Mol file: 112925-76-5.mol

Synonyms:4'-N-ε-Boc-lysyl)>primaquine

Chemical Property of 4'-N-ε-Boc-lysyl)>primaquine

Chemical Property:

Purity/Quality:

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Technology Process of 4'-N-ε-Boc-lysyl)>primaquine

There total 3 articles about 4'-N-ε-Boc-lysyl)>primaquine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

Nα-benzyloxycarbonyl-D-alanyl-L-leucine (30611-60-0) + tert-butyl [(5S)-5-amino-6-({4-[(6-methoxyquinolin-8-yl)amino]pentyl}amino)-6-oxohexyl]carbamate → 4'-N-ε-Boc-lysyl)>primaquine (112925-76-5)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 4.5h;

DOI:10.1021/jm00399a032

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) → 4'-N-ε-Boc-lysyl)>primaquine (112925-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / triethylamine, HOBt, DCC / CH₂Cl₂; dimethylformamide / 1.) 0 deg C, 4 h, 2.) RT, overnight

2: 87 percent / hydrogen / 10percent Pd/C / methanol / 0.67 h

3: 64 percent / HOBt, DCC / dimethylformamide; CH₂Cl₂ / 4.5 h / 0 °C

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00399a032

Reference yield:

4'-N-(Nε-boc-N-Cbz-lysyl)primaquine → 4'-N-ε-Boc-lysyl)>primaquine (112925-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / hydrogen / 10percent Pd/C / methanol / 0.67 h

2: 64 percent / HOBt, DCC / dimethylformamide; CH₂Cl₂ / 4.5 h / 0 °C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00399a032

upstream raw materials:

Nα-benzyloxycarbonyl-D-alanyl-L-leucine

Z-Lys(Boc)-OH