2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester

Base Information

• Chemical Name: 2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester
• CAS No.: 156143-52-1
• Molecular Formula: C₃₀H₃₃NO₄
• Molecular Weight: 471.596
• Mol file: 156143-52-1.mol

Synonyms:2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester

Chemical Property of 2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester

There total 1 articles about 2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

ethyl N-diphenylmethylene glycine (69555-14-2) + α-(4-bromomethylphenyl)acetic acid tert-butyl ester (77292-91-2) → 2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester (156143-52-1)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; potassium iodide; In 1,4-dioxane; water; for 3h; Ambient temperature;

DOI:10.1021/jm00035a014

Reference yield: 72.0%

2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester (156143-52-1) → 2-Amino-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester (156143-53-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 4h; Ambient temperature;

DOI:10.1021/jm00035a014

Reference yield:

2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester (156143-52-1) → [4-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenyl]-acetic acid tert-butyl ester (156143-55-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / 1 N aq. HCl / diethyl ether / 4 h / Ambient temperature

2: 97 percent / dimethylformamide

3: 50 percent / NaBH₄ / ethanol; H₂O / 4 h / 50 °C

With hydrogenchloride; sodium tetrahydroborate; In diethyl ether; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00035a014

upstream raw materials:

ethyl N-diphenylmethylene glycine

α-(4-bromomethylphenyl)acetic acid tert-butyl ester

Downstream raw materials:

2-Amino-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester

[4-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenyl]-acetic acid tert-butyl ester

[4-(3-Acetylsulfanyl-2-tert-butoxycarbonylamino-propyl)-phenyl]-acetic acid tert-butyl ester

2-tert-Butoxycarbonylamino-3-(4-tert-butoxycarbonylmethyl-phenyl)-propionic acid ethyl ester