ethyl 3-amino>propanoate

Base Information

• Chemical Name: ethyl 3-amino>propanoate
• CAS No.: 121731-63-3
• Molecular Formula: C₁₆H₂₃NO₄S
• Molecular Weight: 325.429
• Mol file: 121731-63-3.mol

Synonyms:ethyl 3-amino>propanoate

Chemical Property of ethyl 3-amino>propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-amino>propanoate

There total 1 articles about ethyl 3-amino>propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(S)-N-(1-methyl-2-propen-1-yl) p-toluenesulfonamide (121731-61-1) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 3-amino>propanoate (121731-63-3)

Guidance literature:

With potassium carbonate; In acetonitrile; for 12h; Heating;

DOI:10.1021/jo00278a024

Reference yield: 90.0%

ethyl 3-amino>propanoate (121731-63-3) → N-(2-formylethyl)-N-<(1'S)-1'-methyl-2'-propenyl>-p-toluenesulfonamide (121731-65-5)

Guidance literature:

With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 2h;

DOI:10.1021/jo00278a024

Reference yield:

ethyl 3-amino>propanoate (121731-63-3) → 6-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-(toluene-4-sulfonyl)-1,2,3,4,4a,7,8,8a-octahydro-isoquinoline

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / diisobutylaluminum hydride (DIBAL) / toluene; hexane / 2 h / -78 °C

2: 87 percent / NaH / tetrahydrofuran / 1.5 h / 0 °C

3: 93 percent / Et₃N / diethyl ether / 1.5 h / 0 °C

4: 98 percent / toluene / 96 h / 180 °C

With sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; toluene;

DOI:10.1021/jo00278a024

upstream raw materials:

(S)-N-(1-methyl-2-propen-1-yl) p-toluenesulfonamide

ethyl acrylate

Downstream raw materials:

N-(2-formylethyl)-N-<(1'S)-1'-methyl-2'-propenyl>-p-toluenesulfonamide

N-<5-oxo-3(E)-hexenyl>-N-<(1'S)-1'-methyl-2'-propenyl>-p-toluenesulfonamide

N-<5-<(tert-butyldimethylsilyl)oxy>-3(E),5-hexadienyl>-N-<(1'S)-1'-methyl-2'-propenyl>-p-toluenesulfonamide

(1S,4S,8R)-cis-1,3,4,4a,5,7,8a-octahydro-1-methyl-2-(p-tolylsulfonyl)-6(2H)-isoquinolone