Technology Process of ((4E,8E,12E)-1,1-Diethoxy-4,9,13,17-tetramethyl-octadeca-4,8,12,16-tetraene-6-sulfonyl)-benzene
There total 1 articles about ((4E,8E,12E)-1,1-Diethoxy-4,9,13,17-tetramethyl-octadeca-4,8,12,16-tetraene-6-sulfonyl)-benzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
((E)-6,6-Diethoxy-3-methyl-hex-2-ene-1-sulfonyl)-benzene;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
farnesyl bromide;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone;
In
tetrahydrofuran;
at -78 ℃;
for 0.166667h;
DOI:10.1021/ja050340q
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 92 percent / dppp; LiBHEt3 / (Pd(π-allyl)Cl)2 / tetrahydrofuran / 0.75 h / 20 °C
2: 91 percent / Amberlyst-15; water / acetone / 3 h / 20 °C
3: 100 percent / NiCl2; CrCl2 / dimethylformamide / 2 h / 0 - 20 °C
With
chromium dichloride; amberlyst-15; 1,3-bis-(diphenylphosphino)propane; water; lithium triethylborohydride; nickel dichloride;
bis(η3-allyl-μ-chloropalladium(II));
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja050340q
-
-
(4Z,8E,12E,16E)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-8,13,17,21-tetramethyl-docosa-4,8,12,16,20-pentaenoic acid ethyl ester
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / dppp; LiBHEt3 / (Pd(π-allyl)Cl)2 / tetrahydrofuran / 0.75 h / 20 °C
2: 91 percent / Amberlyst-15; water / acetone / 3 h / 20 °C
3: 100 percent / NiCl2; CrCl2 / dimethylformamide / 2 h / 0 - 20 °C
4: 12 h / 100 °C
With
chromium dichloride; amberlyst-15; 1,3-bis-(diphenylphosphino)propane; water; lithium triethylborohydride; nickel dichloride;
bis(η3-allyl-μ-chloropalladium(II));
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja050340q
