C₂₃H₂₇F₂N₇O₇S

Base Information

• Chemical Name: C₂₃H₂₇F₂N₇O₇S
• CAS No.: 1402738-65-1
• Molecular Formula: C₂₃H₂₇F₂N₇O₇S
• Molecular Weight: 583.573
• Mol file: 1402738-65-1.mol

Synonyms:C₂₃H₂₇F₂N₇O₇S

Chemical Property of C₂₃H₂₇F₂N₇O₇S

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of C₂₃H₂₇F₂N₇O₇S

There total 3 articles about C₂₃H₂₇F₂N₇O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

2-chloro-5-fluoro-4-methoxy-6-methyl-pyrimidine (1192479-35-8) + C17H22FN5O6S (1402738-64-0) → C23H27F2N7O7S (1402738-65-1)

Guidance literature:

With sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In toluene; at 65 ℃; for 3.5h; Inert atmosphere;

Reference yield:

C19H21F4N5O7S (1402738-63-9) → C23H27F2N7O7S (1402738-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; water / methanol / 1 h / 20 °C

2: sodium t-butanolate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / toluene / 3.5 h / 65 °C / Inert atmosphere

With water; potassium carbonate; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In methanol; toluene;

Reference yield:

2,4-dichloro-5-fluoro-6-methyl-pyrimidine (954220-98-5) → C23H27F2N7O7S (1402738-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C

2: sodium t-butanolate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / toluene / 3.5 h / 65 °C / Inert atmosphere

With sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In tetrahydrofuran; methanol; toluene;

upstream raw materials:

2,4-dichloro-5-fluoro-6-methyl-pyrimidine

2-chloro-5-fluoro-4-methoxy-6-methyl-pyrimidine

C₁₇H₂₂FN₅O₆S

C₁₉H₂₁F₄N₅O₇S

Downstream raw materials:

C₂₃H₂₉F₂N₇O₅S

C₂₉H₃₁F₃N₈O₆S