2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethylamine

Base Information

Chemical Name:2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethylamine
CAS No.:851122-01-5
Molecular Formula:C₃₄H₄₁NO₄Si
Molecular Weight:555.789
Hs Code.:

2-benzyloxy-1-[5-(<i>tert</i>-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethylamine

Synonyms:2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethylamine

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Chemical Property of 2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethylamine

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Technology Process of 2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethylamine

There total 8 articles about 2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851121-81-8
[5-(1-azido-2-benzyloxy-ethyl)-3,4-dimethoxy-2-methyl-phenoxy]-tert-butyl-diphenyl-silane

: 851122-01-5
2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 15h; under 760 Torr;
DOI:10.1021/ja050203t

Reference yield:

: 851121-78-3
(5-bromo-3,4-dimethoxy-2-methyl-phenoxy)-tert-butyl-diphenyl-silane

: 851122-01-5
2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane; toluene / 0.33 h / -78 °C

1.2: 80 percent / toluene; tetrahydrofuran; hexane / 0.83 h / -78 °C

2.1: TEA; formic acid; (R,R)-(TosHN-CHPh-CHPh-NH₂) / (RuCl₂)2(p-cymene) / dimethylformamide / 48 h / 40 °C

3.1: DPPA; DBU / toluene; dimethylformamide / 36 h / 50 °C

4.1: H₂ / Pd/C / ethyl acetate / 15 h / 20 °C / 760 Torr

With n-butyllithium; formic acid; TEA; diphenyl-phosphinic acid; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; palladium on activated charcoal; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja050203t

Reference yield:

: 851121-79-4
2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethanone

: 851122-01-5
2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: TEA; formic acid; (R,R)-(TosHN-CHPh-CHPh-NH₂) / (RuCl₂)2(p-cymene) / dimethylformamide / 48 h / 40 °C

2: DPPA; DBU / toluene; dimethylformamide / 36 h / 50 °C

3: H₂ / Pd/C / ethyl acetate / 15 h / 20 °C / 760 Torr

With formic acid; TEA; diphenyl-phosphinic acid; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; palladium on activated charcoal; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja050203t