Technology Process of 2-(pyrrolidin-3-yl)-1,2,4,10-tetrahydro-3-oxa-10-azaphenanthren-9-one hydrochloride
There total 1 articles about 2-(pyrrolidin-3-yl)-1,2,4,10-tetrahydro-3-oxa-10-azaphenanthren-9-one hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere
1.2: 20 °C
1.3: 3 h / 20 °C
2.1: pyridinium chlorochromate; silica gel / dichloromethane / 20 °C
3.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 15 h / 80 - 90 °C
4.1: ammonia / methanol / 1 h / 140 °C / Microwave irradiation
5.1: acetyl chloride / methanol / 72 h / 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); ammonia; silica gel; caesium carbonate; acetyl chloride; pyridinium chlorochromate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid;
In
1,4-dioxane; methanol; dichloromethane;
1.1: |Prins-Kriewitz Hydroxyinethylation;
DOI:10.1021/acsmedchemlett.5b00251
