(1S,2R,3S,4S)-2,3-bis[(tert-butyldiphenylsilyloxy)methyl]-4-(3,4-dimethoxyphenyl)-1-(3,4-methylenedioxyphenyl)-4-triethylsilyloxy-1-butanol

Base Information

• Chemical Name: (1S,2R,3S,4S)-2,3-bis[(tert-butyldiphenylsilyloxy)methyl]-4-(3,4-dimethoxyphenyl)-1-(3,4-methylenedioxyphenyl)-4-triethylsilyloxy-1-butanol
• CAS No.: 1029916-14-0
• Molecular Formula: C₅₉H₇₆O₈Si₃
• Molecular Weight: 997.504
• Mol file: 1029916-14-0.mol

Synonyms:(1S,2R,3S,4S)-2,3-bis[(tert-butyldiphenylsilyloxy)methyl]-4-(3,4-dimethoxyphenyl)-1-(3,4-methylenedioxyphenyl)-4-triethylsilyloxy-1-butanol

Chemical Property of (1S,2R,3S,4S)-2,3-bis[(tert-butyldiphenylsilyloxy)methyl]-4-(3,4-dimethoxyphenyl)-1-(3,4-methylenedioxyphenyl)-4-triethylsilyloxy-1-butanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,3S,4S)-2,3-bis[(tert-butyldiphenylsilyloxy)methyl]-4-(3,4-dimethoxyphenyl)-1-(3,4-methylenedioxyphenyl)-4-triethylsilyloxy-1-butanol

There total 1 articles about (1S,2R,3S,4S)-2,3-bis[(tert-butyldiphenylsilyloxy)methyl]-4-(3,4-dimethoxyphenyl)-1-(3,4-methylenedioxyphenyl)-4-triethylsilyloxy-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(2R,3R,4S)-3-[(tert-butyldiphenylsilyloxy)methyl]-2-[(S)-(3,4-dimethoxyphenyl)(triethylsilyloxy)methyl]-4-(3,4-methylenedioxyphenyl)-4-butanolide + tert-butylchlorodiphenylsilane (58479-61-1) → (1S,2R,3S,4S)-2,3-bis[(tert-butyldiphenylsilyloxy)methyl]-4-(3,4-dimethoxyphenyl)-1-(3,4-methylenedioxyphenyl)-4-triethylsilyloxy-1-butanol (1029916-14-0)

Guidance literature:

(2R,3R,4S)-3-[(tert-butyldiphenylsilyloxy)methyl]-2-[(S)-(3,4-dimethoxyphenyl)(triethylsilyloxy)methyl]-4-(3,4-methylenedioxyphenyl)-4-butanolide; With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 16h;

tert-butylchlorodiphenylsilane; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h; Further stages.;

DOI:10.1271/bbb.70236

Reference yield: 98.0%

(1S,2R,3S,4S)-2,3-bis[(tert-butyldiphenylsilyloxy)methyl]-4-(3,4-dimethoxyphenyl)-1-(3,4-methylenedioxyphenyl)-4-triethylsilyloxy-1-butanol (1029916-14-0) → (2R,3S,4R,5S)-3,4-bis[(tert-butyldiphenylsilyloxy)methyl]-2-(3,4-dimethoxyphenyl)-5-(3,4-methylenedioxyphenyl)tetrahydrofuran (1029916-11-7)

Guidance literature:

With triethylamine; Methanesulfonic anhydride; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1271/bbb.70236

Reference yield: 52.0%

(1S,2R,3S,4S)-2,3-bis[(tert-butyldiphenylsilyloxy)methyl]-4-(3,4-dimethoxyphenyl)-1-(3,4-methylenedioxyphenyl)-4-triethylsilyloxy-1-butanol (1029916-14-0) → C53H62O8Si2

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1271/bbb.70236

upstream raw materials:

tert-butylchlorodiphenylsilane

Downstream raw materials:

(2R,3S,4R,5S)-3,4-bis[(tert-butyldiphenylsilyloxy)methyl]-2-(3,4-dimethoxyphenyl)-5-(3,4-methylenedioxyphenyl)tetrahydrofuran