14-epi-2-methylene-1α,25-dihydroxy-19-nortachysterol

Base Information

Chemical Name:14-epi-2-methylene-1α,25-dihydroxy-19-nortachysterol
CAS No.:1298075-91-8
Molecular Formula:C₂₇H₄₂O₃
Molecular Weight:414.629
Hs Code.:

Synonyms:14-epi-2-methylene-1α,25-dihydroxy-19-nortachysterol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 14-epi-2-methylene-1α,25-dihydroxy-19-nortachysterol

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Technology Process of 14-epi-2-methylene-1α,25-dihydroxy-19-nortachysterol

There total 7 articles about 14-epi-2-methylene-1α,25-dihydroxy-19-nortachysterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1101133-55-4
(1R,3aS,7aR)-1-[(R)-6-triethylsilanyloxy-6-methylheptan-2-yl]-7a-methylhexahydro-1H-inden-4(2H)-one

: 1298075-91-8
14-epi-2-methylene-1α,25-dihydroxy-19-nortachysterol

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 4 h / 80 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene; 2.2: Stille coupling;
DOI:10.1021/ja201481j

Reference yield:

: 1227058-15-2
C₂₀H₄₀O₃Si₂

: 1298075-91-8
14-epi-2-methylene-1α,25-dihydroxy-19-nortachysterol

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra-n-propylammonium perruthenate.; 4-methylmorpholine N-oxide / dichloromethane / 0 - 20 °C / Molecular sieve; Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2.25 h / -78 - 0 °C / Inert atmosphere

3.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 4 h / 80 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With n-butyllithium; tetra-n-propylammonium perruthenate.; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; 3.2: Stille coupling;
DOI:10.1021/ja201481j

Reference yield:

: 1227058-13-0
(3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-1-ethynyl-4-methylenecyclohex-1-ene

: 1298075-91-8
14-epi-2-methylene-1α,25-dihydroxy-19-nortachysterol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 4 h / 80 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; In tetrahydrofuran; toluene; 1.2: Stille coupling;
DOI:10.1021/ja201481j