6-benzenesulfonyl-9-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-10-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-oxo-decanoic acid

Base Information

Chemical Name:6-benzenesulfonyl-9-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-10-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-oxo-decanoic acid
CAS No.:856660-76-9
Molecular Formula:C₄₆H₅₈N₂O₁₀SSi
Molecular Weight:859.125
Hs Code.:

6-benzenesulfonyl-9-benzyloxycarbonylamino-2-<i>tert</i>-butoxycarbonylamino-10-(<i>tert</i>-butyl-diphenyl-silanyloxy)-6-methyl-5-oxo-decanoic acid

Synonyms:6-benzenesulfonyl-9-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-10-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-oxo-decanoic acid

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Chemical Property of 6-benzenesulfonyl-9-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-10-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-oxo-decanoic acid

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Technology Process of 6-benzenesulfonyl-9-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-10-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-oxo-decanoic acid

There total 17 articles about 6-benzenesulfonyl-9-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-10-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-oxo-decanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 856660-75-8
4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-4-methyl-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 856660-76-9
6-benzenesulfonyl-9-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-10-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-oxo-decanoic acid

Guidance literature:: With jones' reagent; In acetone; at 0 ℃; for 6h;
DOI:10.1002/ejoc.200400709

Reference yield:

: 856660-74-7
4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 856660-76-9
6-benzenesulfonyl-9-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-10-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-oxo-decanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / K₂CO₃ / dimethylformamide / 8 h / 20 °C

2: 72 percent / Jones' reagent / acetone / 6 h / 0 °C

With jones' reagent; potassium carbonate; In N,N-dimethyl-formamide; acetone;
DOI:10.1002/ejoc.200400709

Reference yield:

: 1155-62-0
N-benzyloxycarbonyl-L-glutamic acid

: 856660-76-9
6-benzenesulfonyl-9-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-10-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-oxo-decanoic acid

Guidance literature:: Multi-step reaction with 12 steps

1: 98 percent / BF₃*OEt₂

2: 79 percent / LiBH₄ / methanol; tetrahydrofuran / 4 h / 0 °C

3: 88 percent / pTsOH / CH₂Cl₂ / 24 h / 20 °C

4: 27.4 g / Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

5: tetrahydrofuran / 1 h / 0 - 20 °C

6: 31.4 g / magnesium monoperoxy phthalate / ethanol / 0 °C

7: 24.1 g / CeCl₃*7H₂O; (COOH)2 / acetonitrile / 20 °C

8: 38.6 g / imidazole / dimethylformamide / 2 h / 20 °C

9: 85 percent / nBuLi / tetrahydrofuran; hexane / 2.33 h / -78 - 20 °C

10: 95 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 4 h / 20 °C

11: 97 percent / K₂CO₃ / dimethylformamide / 8 h / 20 °C

12: 72 percent / Jones' reagent / acetone / 6 h / 0 °C

With 1H-imidazole; lithium borohydride; n-butyllithium; jones' reagent; cerium(III) chloride; boron trifluoride diethyl etherate; oxalic acid; potassium carbonate; toluene-4-sulfonic acid; magnesium monoperoxyphthalate hexahydrate; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1002/ejoc.200400709