(1S,2S,3R,4R)-4-acetoxymethyl-2,3-isopropylidenedioxycyclopentane-1-methanol α-methoxy-α-trifluoromethylphenylacetate

Base Information

• Chemical Name: (1S,2S,3R,4R)-4-acetoxymethyl-2,3-isopropylidenedioxycyclopentane-1-methanol α-methoxy-α-trifluoromethylphenylacetate
• CAS No.: 151267-01-5
• Molecular Formula: C₂₂H₂₇F₃O₇
• Molecular Weight: 460.447
• Mol file: 151267-01-5.mol

Synonyms:(1S,2S,3R,4R)-4-acetoxymethyl-2,3-isopropylidenedioxycyclopentane-1-methanol α-methoxy-α-trifluoromethylphenylacetate

Chemical Property of (1S,2S,3R,4R)-4-acetoxymethyl-2,3-isopropylidenedioxycyclopentane-1-methanol α-methoxy-α-trifluoromethylphenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,3R,4R)-4-acetoxymethyl-2,3-isopropylidenedioxycyclopentane-1-methanol α-methoxy-α-trifluoromethylphenylacetate

There total 2 articles about (1S,2S,3R,4R)-4-acetoxymethyl-2,3-isopropylidenedioxycyclopentane-1-methanol α-methoxy-α-trifluoromethylphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + (1R,2R,3S,4S)-(4-hydroxymethyl-2,3-isopropylidenedioxy-1-cyclopentyl)methyl acetate (145260-33-9) → (1S,2S,3R,4R)-4-acetoxymethyl-2,3-isopropylidenedioxycyclopentane-1-methanol α-methoxy-α-trifluoromethylphenylacetate (151267-01-5)

Guidance literature:

With pyridine; In tetrachloromethane;

DOI:10.1016/S0040-4020(01)00968-1

Reference yield:

(2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4,6-diyl)dimethanol (59210-93-4) → (1S,2S,3R,4R)-4-acetoxymethyl-2,3-isopropylidenedioxycyclopentane-1-methanol α-methoxy-α-trifluoromethylphenylacetate (151267-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Pseudomonas fluorescens lipase / 30 h

2: pyridine / CCl₄

With pyridine; pseudomonas fluorescens lipase; In tetrachloromethane;

DOI:10.1016/S0040-4020(01)00968-1

upstream raw materials:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(1R,2R,3S,4S)-(4-hydroxymethyl-2,3-isopropylidenedioxy-1-cyclopentyl)methyl acetate

(2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4,6-diyl)dimethanol