tert-butyl [(1S)-2-{[(1S)-1-cyclohexyl-2-{(1aS,4S,6aR,7aS)-4-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]octahydro-5H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-5-yl}-2-oxoethyl]amino}-1-methyl-2-oxoethyl]methylcarbamate

Base Information

Chemical Name:tert-butyl [(1S)-2-{[(1S)-1-cyclohexyl-2-{(1aS,4S,6aR,7aS)-4-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]octahydro-5H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-5-yl}-2-oxoethyl]amino}-1-methyl-2-oxoethyl]methylcarbamate
CAS No.:1266231-72-4
Molecular Formula:C₃₅H₅₁N₅O₆
Molecular Weight:637.82
Hs Code.:

tert-butyl [(1S)-2-{[(1S)-1-cyclohexyl-2-{(1aS,4S,6aR,7aS)-4-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]octahydro-5H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-5-yl}-2-oxoethyl]amino}-1-methyl-2-oxoethyl]methylcarbamate

Synonyms:tert-butyl [(1S)-2-{[(1S)-1-cyclohexyl-2-{(1aS,4S,6aR,7aS)-4-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]octahydro-5H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-5-yl}-2-oxoethyl]amino}-1-methyl-2-oxoethyl]methylcarbamate

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Chemical Property of tert-butyl [(1S)-2-{[(1S)-1-cyclohexyl-2-{(1aS,4S,6aR,7aS)-4-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]octahydro-5H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-5-yl}-2-oxoethyl]amino}-1-methyl-2-oxoethyl]methylcarbamate

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Technology Process of tert-butyl [(1S)-2-{[(1S)-1-cyclohexyl-2-{(1aS,4S,6aR,7aS)-4-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]octahydro-5H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-5-yl}-2-oxoethyl]amino}-1-methyl-2-oxoethyl]methylcarbamate

There total 20 articles about tert-butyl [(1S)-2-{[(1S)-1-cyclohexyl-2-{(1aS,4S,6aR,7aS)-4-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]octahydro-5H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-5-yl}-2-oxoethyl]amino}-1-methyl-2-oxoethyl]methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₆N₄O₃*(x)ClH

: 16948-16-6
N-(tert-butoxycarbonyl)-N-methyl-L-alanine

: 1266231-72-4
tert-butyl [(1S)-2-{[(1S)-1-cyclohexyl-2-{(1aS,4S,6aR,7aS)-4-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]octahydro-5H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-5-yl}-2-oxoethyl]amino}-1-methyl-2-oxoethyl]methylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 16948-16-6
N-(tert-butoxycarbonyl)-N-methyl-L-alanine

: C₂₆H₃₅N₃O₄

: 1266231-72-4
tert-butyl [(1S)-2-{[(1S)-1-cyclohexyl-2-{(1aS,4S,6aR,7aS)-4-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]octahydro-5H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-5-yl}-2-oxoethyl]amino}-1-methyl-2-oxoethyl]methylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2013.07.020

Reference yield:

: C₁₁H₁₇NO₃

: 1266231-72-4
tert-butyl [(1S)-2-{[(1S)-1-cyclohexyl-2-{(1aS,4S,6aR,7aS)-4-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]octahydro-5H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-5-yl}-2-oxoethyl]amino}-1-methyl-2-oxoethyl]methylcarbamate

Guidance literature:: Multi-step reaction with 11 steps

1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 18 h / 20 °C

2: hydrogenchloride / ethyl acetate / 3 h / 20 °C

3: triethylamine / toluene / 18 h / 90 °C

4: palladium 10% on activated carbon; hydrogenchloride; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

5: sodium hydrogencarbonate / tetrahydrofuran / 18 h / 20 °C

6: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 50 °C

7: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

8: hydrogenchloride / ethyl acetate; methanol / 3 h / 20 °C

9: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

10: hydrogenchloride / ethyl acetate / 3.5 h / 20 °C

11: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2013.07.020