Technology Process of N-tosyl-1,2,5,6-tetrahydro-3,4′-bipyridine
There total 6 articles about N-tosyl-1,2,5,6-tetrahydro-3,4′-bipyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
titanium(IV) isopropylate; chloroformic acid ethyl ester; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; water;
DOI:10.1039/c3ob42039f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 0.33 h / 0 °C
2.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C
2.2: 1 h / -78 - 20 °C
3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 °C
3.2: 0 - 20 °C
4.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C
5.1: trifluorormethanesulfonic acid / 1,4-dioxane / 12 h / 120 °C
With
trifluorormethanesulfonic acid; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine; 9-bora-bicyclo[3.3.1]nonane;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
4.1: |Dess-Martin Oxidation;
DOI:10.1039/c3ob42039f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C
1.2: 1 h / -78 - 20 °C
2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 °C
2.2: 0 - 20 °C
3.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C
4.1: trifluorormethanesulfonic acid / 1,4-dioxane / 12 h / 120 °C
With
trifluorormethanesulfonic acid; potassium hexamethylsilazane; Dess-Martin periodane; 9-bora-bicyclo[3.3.1]nonane;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
3.1: |Dess-Martin Oxidation;
DOI:10.1039/c3ob42039f
