2-(2-nitrophenyl)-3'-phenyl-3,4-dihydro-2H,4'H-spiro[benzo[f][1,2]thiazepine-5,5'-isoxazole] 1,1-dioxide

Base Information

Chemical Name:2-(2-nitrophenyl)-3'-phenyl-3,4-dihydro-2H,4'H-spiro[benzo[f][1,2]thiazepine-5,5'-isoxazole] 1,1-dioxide
CAS No.:1582316-86-6
Molecular Formula:C₂₃H₁₉N₃O₅S
Molecular Weight:449.487
Hs Code.:

Synonyms:2-(2-nitrophenyl)-3'-phenyl-3,4-dihydro-2H,4'H-spiro[benzo[f][1,2]thiazepine-5,5'-isoxazole] 1,1-dioxide

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Chemical Property of 2-(2-nitrophenyl)-3'-phenyl-3,4-dihydro-2H,4'H-spiro[benzo[f][1,2]thiazepine-5,5'-isoxazole] 1,1-dioxide

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Technology Process of 2-(2-nitrophenyl)-3'-phenyl-3,4-dihydro-2H,4'H-spiro[benzo[f][1,2]thiazepine-5,5'-isoxazole] 1,1-dioxide

There total 4 articles about 2-(2-nitrophenyl)-3'-phenyl-3,4-dihydro-2H,4'H-spiro[benzo[f][1,2]thiazepine-5,5'-isoxazole] 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1582316-79-7
5-methylene-2-(2-nitrophenyl)-2,3,4,5-tetrahydrobenzo[f][1,2]thiazepine 1,1-dioxide

: 932-90-1
Benzaldoxime

: 1582316-86-6
2-(2-nitrophenyl)-3'-phenyl-3,4-dihydro-2H,4'H-spiro[benzo[f][1,2]thiazepine-5,5'-isoxazole] 1,1-dioxide

Guidance literature:: With sodium hypochlorite; In dichloromethane; water; at 0 ℃; regioselective reaction;
DOI:10.1071/CH13444

Reference yield:

: 1304050-40-5
2-bromo-N-(2-nitrophenyl)benzenesulfonamide

: 1582316-86-6
2-(2-nitrophenyl)-3'-phenyl-3,4-dihydro-2H,4'H-spiro[benzo[f][1,2]thiazepine-5,5'-isoxazole] 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 3.17 h / 20 °C

2: triethylamine; triphenylphosphine; palladium diacetate / acetonitrile / 1.5 h / 20 - 100 °C / Microwave irradiation

3: sodium hypochlorite / dichloromethane; water / 0 °C

With sodium hypochlorite; di-isopropyl azodicarboxylate; palladium diacetate; triethylamine; triphenylphosphine; In dichloromethane; water; acetonitrile; 1: |Mitsunobu Displacement / 2: |Heck Reaction;
DOI:10.1071/CH13444

Reference yield:

: 1582316-72-0
2-bromo-N-(but-3-en-1-yl)-N-(2-nitrophenyl)benzenesulfonamide

: 1582316-86-6
2-(2-nitrophenyl)-3'-phenyl-3,4-dihydro-2H,4'H-spiro[benzo[f][1,2]thiazepine-5,5'-isoxazole] 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; triphenylphosphine; palladium diacetate / acetonitrile / 1.5 h / 20 - 100 °C / Microwave irradiation

2: sodium hypochlorite / dichloromethane; water / 0 °C

With sodium hypochlorite; palladium diacetate; triethylamine; triphenylphosphine; In dichloromethane; water; acetonitrile; 1: |Heck Reaction;
DOI:10.1071/CH13444