1-(5-tert-butyl-2-(3-hydroxy-propyl)-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(2,6-dichlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

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Chemical Name:1-(5-tert-butyl-2-(3-hydroxy-propyl)-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(2,6-dichlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea
CAS No.:1443247-58-2
Molecular Formula:C₃₃H₃₅Cl₂N₇O₃
Molecular Weight:648.592
Hs Code.:

1-(5-tert-butyl-2-(3-hydroxy-propyl)-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(2,6-dichlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

Synonyms:1-(5-tert-butyl-2-(3-hydroxy-propyl)-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(2,6-dichlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

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Chemical Property of 1-(5-tert-butyl-2-(3-hydroxy-propyl)-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(2,6-dichlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

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Technology Process of 1-(5-tert-butyl-2-(3-hydroxy-propyl)-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(2,6-dichlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

There total 12 articles about 1-(5-tert-butyl-2-(3-hydroxy-propyl)-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(2,6-dichlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1443248-64-3
(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-ylamine

: 1443248-84-7
[5-tert-butyl-2-(3-hydroxy-propyl)-2H-pyrazol-3-yl]-carbamic acid 2,2,2-trichloroethyl ester

: 1443247-58-2
1-(5-tert-butyl-2-(3-hydroxy-propyl)-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(2,6-dichlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 70 ℃; for 18h;

Reference yield:

: 1443248-60-9
2,6-dichloro-benzoic acid N'-(5-fluoro-pyridin-2-yl)-hydrazide

: 1443247-58-2
1-(5-tert-butyl-2-(3-hydroxy-propyl)-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(2,6-dichlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; hexachloroethane; triethylamine / tetrahydrofuran / 90 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / 60 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 70 °C

With hexachloroethane; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 23357-52-0
(S)-1,2,3,4-tetrahydronapht-1-yl-amine

: 1443247-58-2
1-(5-tert-butyl-2-(3-hydroxy-propyl)-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(2,6-dichlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / methanol / 18 h / 20 °C

2.1: potassium permanganate; magnesium sulfate monohydrate / water; acetone / 18 h / 20 °C / Cooling with ice

3.1: Noyori's catalyst; formic acid; triethylamine / N,N-dimethyl-formamide / 60 °C / Inert atmosphere; Cooling

4.1: sodium hydroxide; water / methanol / 3.5 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

5.2: 1 h / 60 °C

6.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 70 °C

With potassium permanganate; formic acid; Noyori's catalyst; magnesium sulfate monohydrate; water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetone; mineral oil;