N-{(S)-3-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoyl}-benzenesulfonamide

Base Information

Chemical Name:N-{(S)-3-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoyl}-benzenesulfonamide
CAS No.:1090900-68-7
Molecular Formula:C₃₀H₃₂N₄O₄S
Molecular Weight:544.674
Hs Code.:

Synonyms:N-{(S)-3-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoyl}-benzenesulfonamide

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Chemical Property of N-{(S)-3-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoyl}-benzenesulfonamide

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Technology Process of N-{(S)-3-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoyl}-benzenesulfonamide

There total 8 articles about N-{(S)-3-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoyl}-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 98-10-2
benzenesulfonamide

: 1090898-89-7
(S)-3-[3-(4-methyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzoimidazol-1-yl]-hexanoic acid

: 1090900-68-7
N-{(S)-3-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoyl}-benzenesulfonamide

Guidance literature:: (S)-3-[3-(4-methyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzoimidazol-1-yl]-hexanoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 - 55 ℃; for 1.5h;

benzenesulfonamide; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 27829-72-7
ethyl (E)-hex-2-enoate

: 1090900-68-7
N-{(S)-3-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoyl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - 0 °C

2.1: hydrogen / palladium hydroxide on carbon / ethanol / 16 h / 2068.65 Torr

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 90 °C

4.1: palladium on activated carbon / ethanol / 3 h / 20 °C

5.1: tetrahydrofuran / 12 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 - 100 °C

7.1: lithium hydroxide; water / 1,4-dioxane / 12 h / 20 °C

7.2: 0 °C

8.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 20 - 55 °C

8.2: 0.17 h / 20 °C

8.3: 16 h / 20 °C

With lithium hydroxide; n-butyllithium; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; palladium on activated carbon; palladium hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1090902-96-7
(S)-3-(2-nitro-phenylamino)-hexanoic acid ethyl ester

: 1090900-68-7
N-{(S)-3-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoyl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium on activated carbon / ethanol / 3 h / 20 °C

2.1: tetrahydrofuran / 12 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 - 100 °C

4.1: lithium hydroxide; water / 1,4-dioxane / 12 h / 20 °C

4.2: 0 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 20 - 55 °C

5.2: 0.17 h / 20 °C

5.3: 16 h / 20 °C

With lithium hydroxide; water; potassium carbonate; 1,1'-carbonyldiimidazole; palladium on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;