4-((2S,3R,4R,5S,6S)-3,5-Dihydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-phenyl ester

Base Information

Chemical Name:4-((2S,3R,4R,5S,6S)-3,5-Dihydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-phenyl ester
CAS No.:131675-33-7
Molecular Formula:C₂₃H₂₇IO₈S
Molecular Weight:590.433
Hs Code.:

Synonyms:4-((2S,3R,4R,5S,6S)-3,5-Dihydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-phenyl ester

Suppliers and Price of 4-((2S,3R,4R,5S,6S)-3,5-Dihydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-((2S,3R,4R,5S,6S)-3,5-Dihydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-((2S,3R,4R,5S,6S)-3,5-Dihydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-phenyl ester

There total 13 articles about 4-((2S,3R,4R,5S,6S)-3,5-Dihydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 131675-60-0
3-Iodo-5,6-dimethoxy-4-((2S,3R,4R,5S,6S)-4-methoxy-6-methyl-3,5-bis-triethylsilanyloxy-tetrahydro-pyran-2-yloxy)-2-methyl-thiobenzoic acid S-phenyl ester

: 131675-33-7
4-((2S,3R,4R,5S,6S)-3,5-Dihydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-phenyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1039/c39900001275

Reference yield:

: 73-34-7
L-rhamnose

: 131675-33-7
4-((2S,3R,4R,5S,6S)-3,5-Dihydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-phenyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 1.) dimethylaminopyridine (DMAP), 2.) SnCl₄ / 1.) CH₂Cl₂, 25 deg C, 2.) 0 deg C

2: K₂CO₃ / methanol / 25 °C

3: 1.) n-Bu₂SnO, 2.) CsF / 1.) MeOH, 65 deg C, 2 h, 2.) DMF, 25 deg C, 12 h

4: 95 percent / Et₃N, dimethylaminopyridine (DMAP) / CH₂Cl₂ / 2 h / 0 - 25 °C

5: 85 percent / diaminosulphur trifluoride (DAST), N-bromosuccinimide (NBS) / CH₂Cl₂ / 3 h / -78 - 0 °C

6: 80 percent / AgClO₄, SnCl₂, 4-A molecular sieves / CH₂Cl₂ / 12 h / -20 - 0 °C

7: 100 percent / K₂CO₃ / methanol / 2 h / 25 °C

8: 92 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -20 - 0 °C

9: 90 percent / di-isobutylaluminium hydride (DIBAL) / CH₂Cl₂ / 2 h / -78 - 0 °C

10: 75 percent / RuCl₃ hydrate, NaIO₄ / CCl₄; acetonitrile; H₂O / 3 h / 0 - 25 °C

11: 90 percent / PhOP(O)Cl₂, pyridine / 1,2-dimethoxy-ethane / 1 h / 0 - 25 °C

12: 90 percent / Bu₄NF / tetrahydrofuran / 0.5 h / 0 °C

With pyridine; 2,6-dimethylpyridine; dmap; ruthenium trichloride; sodium periodate; N-Bromosuccinimide; diisobutylaluminum hydride; 4 A molecular sieve; diaminosulphur trifluoride; tetrabutyl ammonium fluoride; silver perchlorate; tin(IV) chloride; di(n-butyl)tin oxide; potassium carbonate; O-phenyl phosphorodichloridate; triethylamine; cesium fluoride; tin(ll) chloride; In tetrahydrofuran; methanol; tetrachloromethane; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;
DOI:10.1039/c39900001275

Reference yield:

: 115592-74-0,115650-45-8,127761-05-1
4-Hydroxy-5-iod-2,3-dimethoxy-6-methyl-benzoesaeuremethylester

: 131675-33-7
4-((2S,3R,4R,5S,6S)-3,5-Dihydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / AgClO₄, SnCl₂, 4-A molecular sieves / CH₂Cl₂ / 12 h / -20 - 0 °C

2: 100 percent / K₂CO₃ / methanol / 2 h / 25 °C

3: 92 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -20 - 0 °C

4: 90 percent / di-isobutylaluminium hydride (DIBAL) / CH₂Cl₂ / 2 h / -78 - 0 °C

5: 75 percent / RuCl₃ hydrate, NaIO₄ / CCl₄; acetonitrile; H₂O / 3 h / 0 - 25 °C

6: 90 percent / PhOP(O)Cl₂, pyridine / 1,2-dimethoxy-ethane / 1 h / 0 - 25 °C

7: 90 percent / Bu₄NF / tetrahydrofuran / 0.5 h / 0 °C

With pyridine; 2,6-dimethylpyridine; ruthenium trichloride; sodium periodate; diisobutylaluminum hydride; 4 A molecular sieve; tetrabutyl ammonium fluoride; silver perchlorate; potassium carbonate; O-phenyl phosphorodichloridate; tin(ll) chloride; In tetrahydrofuran; methanol; tetrachloromethane; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;
DOI:10.1039/c39900001275