Technology Process of (S)-2,2,4-trimethyl-4-phenyl-1,3-dioxolane
There total 4 articles about (S)-2,2,4-trimethyl-4-phenyl-1,3-dioxolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
toluene;
at 80 ℃;
for 2h;
Molecular sieve;
Inert atmosphere;
DOI:10.1002/adsc.201200782
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide; quinine / chloroform / 1 h / 15 °C / Molecular sieve; Inert atmosphere
1.2: Molecular sieve; Inert atmosphere
2.1: toluene-4-sulfonic acid / acetone; dichloromethane / 2 h / 20 °C / Molecular sieve; Inert atmosphere
3.1: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / toluene / 2 h / 80 °C / Molecular sieve; Inert atmosphere
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; quinine; toluene-4-sulfonic acid;
In
dichloromethane; chloroform; acetone; toluene;
1.2: |Sharpless Dihydroxylation;
DOI:10.1002/adsc.201200782
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / acetone; dichloromethane / 2 h / 20 °C / Molecular sieve; Inert atmosphere
2: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / toluene / 2 h / 80 °C / Molecular sieve; Inert atmosphere
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; toluene-4-sulfonic acid;
In
dichloromethane; acetone; toluene;
DOI:10.1002/adsc.201200782
