(E)-2-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-1-trimethylsilanyloxy-cyclohexa-2,4-dienyl]-but-2-ene-1,4-diol

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Chemical Name:(E)-2-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-1-trimethylsilanyloxy-cyclohexa-2,4-dienyl]-but-2-ene-1,4-diol
CAS No.:114066-36-3
Molecular Formula:C₂₁H₄₀O₄Si₂
Molecular Weight:412.717
Hs Code.:

Synonyms:(E)-2-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-1-trimethylsilanyloxy-cyclohexa-2,4-dienyl]-but-2-ene-1,4-diol

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Chemical Property of (E)-2-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-1-trimethylsilanyloxy-cyclohexa-2,4-dienyl]-but-2-ene-1,4-diol

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Technology Process of (E)-2-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-1-trimethylsilanyloxy-cyclohexa-2,4-dienyl]-but-2-ene-1,4-diol

There total 3 articles about (E)-2-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-1-trimethylsilanyloxy-cyclohexa-2,4-dienyl]-but-2-ene-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: (E)-3-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-1-trimethylsilanyloxy-cyclohexa-2,4-dienyl]-4-hydroxy-but-2-enoic acid tert-butyl ester

: 114066-36-3
(E)-2-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-1-trimethylsilanyloxy-cyclohexa-2,4-dienyl]-but-2-ene-1,4-diol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 2h;
DOI:10.1016/S0040-4039(00)96345-7

Reference yield:

: (E)-3-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-1-trimethylsilanyloxy-cyclohexa-2,4-dienyl]-4-hydroxy-but-2-enoic acid

: 114066-36-3
(E)-2-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-1-trimethylsilanyloxy-cyclohexa-2,4-dienyl]-but-2-ene-1,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / K₂CO₃ / 3 h / 80 °C

2: 70 percent / LiAlH₄ / diethyl ether / 2 h

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether;
DOI:10.1016/S0040-4039(00)96345-7

Reference yield:

: 114179-39-4
5(S)-(2-hydroxy-1-oxoethyl)-5-<(trimethylsilyl)oxy>-6(S)-<((tert-butyldimethylsilyl)oxy)methyl>-2-methyl-1,3-cyclohexadiene

: 114066-36-3
(E)-2-[(1S,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-1-trimethylsilanyloxy-cyclohexa-2,4-dienyl]-but-2-ene-1,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / DCC / CH₂Cl₂ / 0.5 h

2: 88 percent / K₂CO₃ / 3 h / 80 °C

3: 70 percent / LiAlH₄ / diethyl ether / 2 h

With lithium aluminium tetrahydride; potassium carbonate; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)96345-7