C₃₀H₂₂F₃N₃O₈

Base Information

• Chemical Name: C₃₀H₂₂F₃N₃O₈
• CAS No.: 631090-59-0
• Molecular Formula: C₃₀H₂₂F₃N₃O₈
• Molecular Weight: 609.515
• Mol file: 631090-59-0.mol

Synonyms:C₃₀H₂₂F₃N₃O₈

Chemical Property of C₃₀H₂₂F₃N₃O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₂₂F₃N₃O₈

There total 5 articles about C₃₀H₂₂F₃N₃O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.5%

<4-nitro-3-(trifluoromethyl)phenoxy>acetic acid (113405-09-7) + 5-ethyl-5-hydroxy-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione (186668-40-6) → C30H22F3N3O8 (631090-59-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1080/10286020.2013.855203

Reference yield:

(-)-O,21-dihydrocamptothecin (210563-62-5) → C30H22F3N3O8 (631090-59-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium periodate / 20 °C

2: zinc; chloro-trimethyl-silane; nitrogen / Reflux

3: trifluoroacetic acid

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

With dmap; sodium periodate; chloro-trimethyl-silane; nitrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; zinc; In dichloromethane;

DOI:10.1080/10286020.2013.855203

Reference yield:

camptothecin (7689-03-4,91926-09-9) → C30H22F3N3O8 (631090-59-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 20 °C

2: sodium periodate / 20 °C

3: zinc; chloro-trimethyl-silane; nitrogen / Reflux

4: trifluoroacetic acid

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

With dmap; sodium tetrahydroborate; sodium periodate; chloro-trimethyl-silane; nitrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; zinc; In methanol; dichloromethane;

DOI:10.1080/10286020.2013.855203

upstream raw materials:

(-)-O,21-dihydrocamptothecin

camptothecin

<4-nitro-3-(trifluoromethyl)phenoxy>acetic acid

5-ethyl-5-hydroxy-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione