ethyl <αS,2S,4R>-α-hydroxy-2-(4-methoxyphenyl)-1,3-dioxane-4-acetate

Base Information

Chemical Name:ethyl <αS,2S,4R>-α-hydroxy-2-(4-methoxyphenyl)-1,3-dioxane-4-acetate
CAS No.:172427-70-2
Molecular Formula:C₁₅H₂₀O₆
Molecular Weight:296.32
Hs Code.:

Synonyms:ethyl <αS,2S,4R>-α-hydroxy-2-(4-methoxyphenyl)-1,3-dioxane-4-acetate

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Chemical Property of ethyl <αS,2S,4R>-α-hydroxy-2-(4-methoxyphenyl)-1,3-dioxane-4-acetate

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Technology Process of ethyl <αS,2S,4R>-α-hydroxy-2-(4-methoxyphenyl)-1,3-dioxane-4-acetate

There total 4 articles about ethyl <αS,2S,4R>-α-hydroxy-2-(4-methoxyphenyl)-1,3-dioxane-4-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 172427-69-9
ethyl <2S,3R>-2,3-dihydroxy-5-(4-methoxybenzyloxy)pentanoate

: 172427-70-2
ethyl <αS,2S,4R>-α-hydroxy-2-(4-methoxyphenyl)-1,3-dioxane-4-acetate

Guidance literature:: With 3 A molecular sieve; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 10 - 15 ℃; for 0.75h;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 172427-70-2
ethyl <αS,2S,4R>-α-hydroxy-2-(4-methoxyphenyl)-1,3-dioxane-4-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium hydride, 2.) tetrabutylammonium iodide / 1) THF, room temperature, 30 min; 2) THF, 2 d

2: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1) CH₂Cl₂, -78 deg C, 40 min; 2) CH₂Cl₂, room temperature, 5 d

3: 51 percent / potassium ferricyanide(III), K₂CO₃, hydroquinidine 1,4-phthalazinediyl diether, osmium tetroxide, methanesulfonamide / 2-methyl-propan-2-ol; H₂O / 96 h / 0 °C

4: 99 percent / 3 Angstroem sieves, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 0.75 h / 10 - 15 °C

With osmium(VIII) oxide; (DHQD)2PHAL; oxalyl dichloride; methanesulfonamide; 3 A molecular sieve; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hexacyanoferrate(III); In dichloromethane; water; tert-butyl alcohol;

Reference yield:

: 135362-69-5
3-(4-methoxybenzyl)oxypropan-1-ol

: 172427-70-2
ethyl <αS,2S,4R>-α-hydroxy-2-(4-methoxyphenyl)-1,3-dioxane-4-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1) CH₂Cl₂, -78 deg C, 40 min; 2) CH₂Cl₂, room temperature, 5 d

2: 51 percent / potassium ferricyanide(III), K₂CO₃, hydroquinidine 1,4-phthalazinediyl diether, osmium tetroxide, methanesulfonamide / 2-methyl-propan-2-ol; H₂O / 96 h / 0 °C

3: 99 percent / 3 Angstroem sieves, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 0.75 h / 10 - 15 °C

With osmium(VIII) oxide; (DHQD)2PHAL; oxalyl dichloride; methanesulfonamide; 3 A molecular sieve; potassium carbonate; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hexacyanoferrate(III); In dichloromethane; water; tert-butyl alcohol;