Nemorensic acid

Base Information

• Chemical Name: Nemorensic acid
• CAS No.: 49715-49-3
• Molecular Formula: C₁₀H₁₆O₅
• Molecular Weight: 216.234
• Mol file: 49715-49-3.mol

Synonyms:Nemorensic acid

Chemical Property of Nemorensic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of Nemorensic acid

There total 1 articles about Nemorensic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-bromo-3-methylcrotonate (51318-62-8,51371-55-2,26918-14-9) → Nemorensic acid (49715-49-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 48 percent / 50percent aq. NaOH / dibenzo-18-crown-6 / benzene / 14 h

2: 80.1 percent / 1.) 5percent aq. NaOH / 1.) room temp., 6 h, 2.) reflux

3: 35percent aq. H₂SO₄ / 0.25 h / Ambient temperature

4: conc. HCl / 1.) 12 h, 2.) 100 deg C, 6 h

With hydrogenchloride; sodium hydroxide; sulfuric acid; dibenzo-18-crown-6; In benzene;

DOI:10.1002/ardp.19803130914

Reference yield:

(E)-6-Hydroxy-3,5,6-trimethyl-hept-2-enedioic acid (49715-49-3) → cis-nemorensic acid (50906-95-1,62057-91-4,95671-22-0)

Guidance literature:

With potassium hydroxide; In ethanol; for 4h; Heating;

upstream raw materials:

ethyl 4-bromo-3-methylcrotonate

Downstream raw materials:

cis-nemorensic acid