{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]biphenyl-4-yl}acetic acid ethyl ester

Base Information

Chemical Name:{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]biphenyl-4-yl}acetic acid ethyl ester
CAS No.:1396007-90-1
Molecular Formula:C₂₉H₂₉N₃O₄
Molecular Weight:483.567
Hs Code.:

Synonyms:{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]biphenyl-4-yl}acetic acid ethyl ester

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Chemical Property of {4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]biphenyl-4-yl}acetic acid ethyl ester

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Technology Process of {4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]biphenyl-4-yl}acetic acid ethyl ester

There total 5 articles about {4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]biphenyl-4-yl}acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.1%

: 1396007-83-2
4-bromo-2-methyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester

: 1396007-84-3
[4'-(4,4,5,5-tetramethyl-[1,3,2]di-oxaborolan-2-yl)-biphenyl-4-yl]-acetic acid ethyl ester

: 1396007-90-1
{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]biphenyl-4-yl}acetic acid ethyl ester

Guidance literature:: With potassium phosphate; palladium diacetate; XPhos; In water; toluene; at 95 ℃; Inert atmosphere; Sealed tube;

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 1396007-90-1
{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]biphenyl-4-yl}acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 80 °C

2: palladium diacetate; XPhos; potassium phosphate / toluene; water / 95 °C / Inert atmosphere; Sealed tube

With potassium phosphate; diphenyl phosphoryl azide; palladium diacetate; triethylamine; XPhos; In water; toluene;

Reference yield:

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1396007-90-1
{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]biphenyl-4-yl}acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 85 °C / Sealed tube; Inert atmosphere

2: triethylamine / dichloromethane / 0.67 h / -78 - 20 °C

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

4: palladium diacetate; XPhos; potassium phosphate / toluene; water / 95 °C / Inert atmosphere; Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; palladium diacetate; potassium carbonate; triethylamine; XPhos; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;