N-(4-fluorobenzyl)-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide

Base Information

Chemical Name:N-(4-fluorobenzyl)-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide
CAS No.:1268706-99-5
Molecular Formula:C₁₆H₁₂FN₃O₃
Molecular Weight:313.288
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide

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Chemical Property of N-(4-fluorobenzyl)-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide

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Technology Process of N-(4-fluorobenzyl)-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide

There total 8 articles about N-(4-fluorobenzyl)-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1268706-87-1
C₂₄H₂₀FN₃O₄

: 1268706-99-5
N-(4-fluorobenzyl)-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide

Guidance literature:: With methoxybenzene; In dichloromethane; trifluoroacetic acid; at 20 ℃; for 0.5h;
DOI:10.1016/j.tetlet.2010.12.033

Reference yield: 54.0%

: 909191-95-3
ethyl 3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxylate

: 140-75-0
para-fluorobenzylamine

: 1268706-99-5
N-(4-fluorobenzyl)-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide

Guidance literature:: In ethanol; for 24h; Reflux;
DOI:10.1002/cmdc.201200058

Reference yield:

: 1268706-61-1
C₁₅H₁₆N₂O₃

: 1268706-99-5
N-(4-fluorobenzyl)-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / acetonitrile / 0.5 h / 80 °C

2: acetonitrile / 6 h / 80 °C

3: methoxybenzene / dichloromethane; trifluoroacetic acid / 0.5 h / 20 °C

With toluene-4-sulfonic acid; methoxybenzene; In dichloromethane; acetonitrile; trifluoroacetic acid;
DOI:10.1016/j.tetlet.2010.12.033