1,2,3,4-TETRAHYDROQUINOLIN-5-AMINE

Base Information

• Chemical Name: 1,2,3,4-TETRAHYDROQUINOLIN-5-AMINE
• CAS No.: 36887-98-6
• Molecular Formula: C9H12 N2
• Molecular Weight: 148.2
• Hs Code.: 2933499090
• Mol file: 36887-98-6.mol

Synonyms:5-Amino-1,2,3,4-tetrahydroquinoline

Chemical Property of 1,2,3,4-TETRAHYDROQUINOLIN-5-AMINE

Chemical Property:

• Boiling Point: 315.4±31.0 °C(Predicted)
• PKA: 5.41±0.20(Predicted)
• PSA: 38.05000
• Density: 1.101±0.06 g/cm3(Predicted)
• LogP: 2.34610
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

1,2,3,4-Tetrahydroquinolin-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-TETRAHYDROQUINOLIN-5-AMINE

There total 4 articles about 1,2,3,4-TETRAHYDROQUINOLIN-5-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

5-nitroquinoline (607-34-1) → 1,2,3,4‐tetrahydroquinolin‐5‐amine (36887-98-6)

Guidance literature:

With Pd/Al₂O₃; hydrogen; In tetrahydrofuran; at 90 ℃; under 22502.3 Torr; Flow reactor;

DOI:10.1021/acs.oprd.1c00164

Reference yield: 84.0%

5-Aminoquinoline (611-34-7,146614-41-7) → 1,2,3,4‐tetrahydroquinolin‐5‐amine (36887-98-6)

Guidance literature:

5-Aminoquinoline; With H₂SiEt₂; tris(pentafluorophenyl)borate; In chloroform; at 85 ℃; for 12h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; at 20 ℃; for 1h;

DOI:10.1055/s-0036-1588442

Reference yield: 70.0%

5-(2-oxocyclopentacarboxamido)-1,2,3,4-tetrahydroquinoline (77738-77-3) → 1,2,3,4‐tetrahydroquinolin‐5‐amine (36887-98-6) + 4,11-diazagona-5,7,9,13-tetraen-12-one (77738-78-4)

Guidance literature:

With PPA; at 100 - 115 ℃; for 1h;

DOI:10.1248/cpb.29.651

upstream raw materials:

5-nitroquinoline

5-(2-oxocyclopentacarboxamido)-1,2,3,4-tetrahydroquinoline

5-Aminoquinoline

Refernces

• 1、 Yan, Jiangkun,Gu, Yanting,Sun, Yixiang,Zhang, Ziheng,Zhang, Xiangyu,Wang, Xinran,Wu, Tianxiao,Zhao, Dongmei,Cheng, Maosheng. "Design, synthesis, and biological evaluation of 5-aminotetrahydroquinoline-based LSD1 inhibitors acting on Asp375". . . Retrieved 2021/05/17.
• 2、 Adhikari, Priyanka,Bhattacharyya, Dipanjan,Das, Animesh,Konwar, Monuranjan,Nandi, Sekhar,Sarmah, Bikash Kumar. "Boric acid catalyzed chemoselective reduction of quinolines". supporting information. p. 1214 - 1220. Retrieved 2020/02/22.