1,1-dimethylethyl 7-[5-(3-cyano-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl 7-[5-(3-cyano-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate
CAS No.:1258855-24-1
Molecular Formula:C₂₄H₂₄N₄O₄
Molecular Weight:432.479
Hs Code.:

Synonyms:1,1-dimethylethyl 7-[5-(3-cyano-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

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Chemical Property of 1,1-dimethylethyl 7-[5-(3-cyano-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

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Technology Process of 1,1-dimethylethyl 7-[5-(3-cyano-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

There total 7 articles about 1,1-dimethylethyl 7-[5-(3-cyano-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258855-25-2
1,1-dimethylethyl 7-(5-{3-cyano-4-[(phenylmethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1258855-24-1
1,1-dimethylethyl 7-[5-(3-cyano-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In toluene; at 20 ℃; under 750.075 Torr;

Reference yield:

: 149354-02-9
1,1-dimethylethyl 7-cyano-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1258855-24-1
1,1-dimethylethyl 7-[5-(3-cyano-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 60 °C / Reflux

2: pyridine / toluene / 2 h / Reflux

3: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / toluene / 20 °C / 750.08 Torr

With pyridine; hydroxylamine hydrochloride; hydrogen; sodium hydride; sodium hydrogencarbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 264264-28-0
1,1-dimethylethyl-7-{[(trifluoromethyl)sulfonyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1258855-24-1
1,1-dimethylethyl 7-[5-(3-cyano-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.25 h / 100 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 60 °C / Reflux

3: pyridine / toluene / 2 h / Reflux

4: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

5: hydrogen / palladium 10% on activated carbon / toluene / 20 °C / 750.08 Torr

With pyridine; hydroxylamine hydrochloride; hydrogen; sodium hydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;