4-(4-CHLORO-PYRAZOL-1-YLMETHYL)-PHENYLAMINE

Base Information

• Chemical Name: 4-(4-CHLORO-PYRAZOL-1-YLMETHYL)-PHENYLAMINE
• CAS No.: 1001862-74-3
• Molecular Formula: C₁₀H₁₀ClN₃
• Molecular Weight: 207.662
• Mol file: 1001862-74-3.mol

Synonyms:4-((4-chloro-1H-pyrazol-1-yl)methyl)aniline

Chemical Property of 4-(4-CHLORO-PYRAZOL-1-YLMETHYL)-PHENYLAMINE

Chemical Property:

• Boiling Point: 395.9±27.0 °C(Predicted)
• PKA: 4.46±0.10(Predicted)
• Density: 1.31±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

4-((4-Chloro-1H-pyrazol-1-yl)methyl)aniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-CHLORO-PYRAZOL-1-YLMETHYL)-PHENYLAMINE

There total 2 articles about 4-(4-CHLORO-PYRAZOL-1-YLMETHYL)-PHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-1H-pyrazole (15878-00-9) + α-bromo-p-toluidine (63516-03-0) → 4-((4-chloro-1H-pyrazol-1-yl)methyl)aniline (1001862-74-3)

Guidance literature:

With potassium phosphate; (2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1 ‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate; In tetrahydrofuran; at 50 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201606601

Reference yield:

4-chloro-1-(4-nitrobenzyl)-1H-pyrazole (512809-55-1) → 4-((4-chloro-1H-pyrazol-1-yl)methyl)aniline (1001862-74-3)

Guidance literature:

With platinum on activated charcoal; hydrogen; In ethyl acetate; at 20 ℃; for 48h;

Reference yield:

4-((4-chloro-1H-pyrazol-1-yl)methyl)aniline (1001862-74-3) → 4-chloro-1-(4-fluorobenzyl)-1H-pyrazole

Guidance literature:

4-((4-chloro-1H-pyrazol-1-yl)methyl)aniline; With lithium tetrafluoroborate; tert.-butylnitrite; trifluoroacetic acid; In acetic acid butyl ester; at 60 ℃; Flow reactor;

With lithium tetrafluoroborate; In acetic acid butyl ester; at 130 ℃; Flow reactor;

DOI:10.1002/anie.201606601

upstream raw materials:

4-chloro-1-(4-nitrobenzyl)-1H-pyrazole

4-chloro-1H-pyrazole

α-bromo-p-toluidine

Refernces

• 1、 -. "HETEROARYL INHIBITORS OF PDE4". Paragraph 0822. . Retrieved 2014/05/24.