5-[(2-Fluoro-5-nitrophenyl)amino]-5-oxopentanoic acid

Base Information

Chemical Name:5-[(2-Fluoro-5-nitrophenyl)amino]-5-oxopentanoic acid
CAS No.:451459-95-3
Molecular Formula:C₁₁H₁₁FN₂O₅
Molecular Weight:270.217
Hs Code.:
DSSTox Substance ID:DTXSID201215119

Synonyms:5-[(2-fluoro-5-nitrophenyl)amino]-5-oxopentanoic acid;Oprea1_142257;SCHEMBL15436046;DTXSID201215119;AKOS001581140;4-(2-fluoro-5-nitrophenylcarbamoyl)butanoic acid;SR-01000103658;SR-01000103658-1;451459-95-3

Suppliers and Price of 5-[(2-Fluoro-5-nitrophenyl)amino]-5-oxopentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5-[(2-Fluoro-5-nitrophenyl)amino]-5-oxopentanoic acid

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:270.06519962
Heavy Atom Count:19
Complexity:358

Purity/Quality:: 98% HPLC ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1[N+](=O)[O-])NC(=O)CCCC(=O)O)F

Technology Process of 5-[(2-Fluoro-5-nitrophenyl)amino]-5-oxopentanoic acid

There total 1 articles about 5-[(2-Fluoro-5-nitrophenyl)amino]-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-55-4
glutaric anhydride,

: 369-36-8
6-fluoro-3-nitroaniline

: 451459-95-3
5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid

Guidance literature:: In toluene; at 70 - 85 ℃; for 4h;

Reference yield:

: 451459-95-3
5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid

: 3543-73-5
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water / 3 h / 75 °C

1.2: 55 - 60 °C

2.1: sulfuric acid / 10 h / Reflux

3.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr

With Iron(III) nitrate nonahydrate; ferrous(II) sulfate heptahydrate; sulfuric acid; 5% Pd/C; hydrogen; In ethanol; water;

Reference yield:

: 451459-95-3
5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid

: 3543-75-7,97832-05-8
bendamustine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: water / 3 h / 75 °C

1.2: 55 - 60 °C

2.1: sulfuric acid / 10 h / Reflux

3.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr

4.1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale

5.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C

6.1: hydrogenchloride / water; acetone / 40 - 75 °C

With hydrogenchloride; Iron(III) nitrate nonahydrate; ferrous(II) sulfate heptahydrate; thionyl chloride; sulfuric acid; 5% Pd/C; hydrogen; potassium carbonate; In ethanol; dichloromethane; water; acetone;