N-(5-(2,5-dichlorophenyl)-2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Base Information

Chemical Name:N-(5-(2,5-dichlorophenyl)-2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:1260162-47-7
Molecular Formula:C₁₉H₁₃Cl₂N₅O
Molecular Weight:398.251
Hs Code.:

Synonyms:N-(5-(2,5-dichlorophenyl)-2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Property of N-(5-(2,5-dichlorophenyl)-2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Technology Process of N-(5-(2,5-dichlorophenyl)-2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 6 articles about N-(5-(2,5-dichlorophenyl)-2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1260168-90-8
N-(5-bromo-2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

: 135145-90-3
2,5-dichlorobenzeneboronic acid

: 1260162-47-7
N-(5-(2,5-dichlorophenyl)-2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; at 120 ℃; for 0.5h; Microwave irradiation; Sealed vial;

Reference yield:

: 25940-35-6
pyrazolo[1,5-a] pyrimidine-3-carboxylic acid

: 1260162-47-7
N-(5-(2,5-dichlorophenyl)-2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / 120 °C

2: triethylamine / dichloromethane / 1 h / 20 °C

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.5 h / 120 °C / Microwave irradiation; Sealed vial

With sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; water; acetonitrile; 3: Suzuki Cross-coupling;

Reference yield:

: 3430-13-5
5-bromo-2-methylpyridine

: 1260162-47-7
N-(5-(2,5-dichlorophenyl)-2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: m-chloroperoxybenzoic acid / chloroform / 4 h / 20 °C

2.1: nitric acid / sulfuric acid / 2 h / 20 - 90 °C

2.2: pH 10

3.1: hydrogenchloride; tin(II) chloride dihdyrate / water / 48 h / 90 °C

3.2: 20 °C

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.5 h / 120 °C / Microwave irradiation; Sealed vial

With hydrogenchloride; m-chloroperoxybenzoic acid; tin(II) chloride dihdyrate; nitric acid; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; chloroform; sulfuric acid; water; acetonitrile; 5.1: Suzuki Cross-coupling;