benzyl (1-((1-acryloylpyrrolidin-2-yl)methyl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

Base Information

Chemical Name:benzyl (1-((1-acryloylpyrrolidin-2-yl)methyl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate
CAS No.:1575819-69-0
Molecular Formula:C₃₇H₄₂ClN₅O₄
Molecular Weight:656.225
Hs Code.:

Synonyms:benzyl (1-((1-acryloylpyrrolidin-2-yl)methyl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

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Chemical Property of benzyl (1-((1-acryloylpyrrolidin-2-yl)methyl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

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Technology Process of benzyl (1-((1-acryloylpyrrolidin-2-yl)methyl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

There total 9 articles about benzyl (1-((1-acryloylpyrrolidin-2-yl)methyl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 1575819-69-0
benzyl (1-((1-acryloylpyrrolidin-2-yl)methyl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

3: sodium hydroxide / 1,4-dioxane; water / 3 h / 10 - 20 °C

4: zinc; ammonium chloride / methanol / 2 h / 50 °C

5: ethanol / 16 h / 20 °C / Inert atmosphere

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

7: dichloromethane / 16 h / 0 - 20 °C

8: toluene; tetrahydrofuran / 2 h / -30 - 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile;

Reference yield:

: 1575819-64-5
benzyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate trifluoroacetate

: 814-68-6,25189-84-8
acryloyl chloride

: 1575819-69-0
benzyl (1-((1-acryloylpyrrolidin-2-yl)methyl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

Guidance literature:: In tetrahydrofuran; toluene; at -30 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1575819-57-6
tert-butyl 2-((4-formyl-2-nitrophenylamino)methyl)pyrrolidine-1-carboxylate

: 1575819-69-0
benzyl (1-((1-acryloylpyrrolidin-2-yl)methyl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

2: sodium hydroxide / 1,4-dioxane; water / 3 h / 10 - 20 °C

3: zinc; ammonium chloride / methanol / 2 h / 50 °C

4: ethanol / 16 h / 20 °C / Inert atmosphere

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

6: dichloromethane / 16 h / 0 - 20 °C

7: toluene; tetrahydrofuran / 2 h / -30 - 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene;