(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)ethanamine

Base Information

Chemical Name:(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)ethanamine
CAS No.:1143521-06-5
Molecular Formula:C₂₀H₁₉ClF₃N₃
Molecular Weight:393.839
Hs Code.:

Synonyms:(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)ethanamine

Suppliers and Price of (1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)ethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)ethanamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)ethanamine

There total 4 articles about (1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethanone

: 24358-43-8,68297-62-1,147200-14-4,17061-53-9
(R)-α-(m-chlorophenyl)ethylamine

: 1143521-06-5
(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)ethanamine

Guidance literature:: 1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethanone; (R)-α-(m-chlorophenyl)ethylamine; With titanium(IV) isopropylate; In tetrahydrofuran; at 35 ℃; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -78 ℃; Inert atmosphere;
DOI:10.1021/jm9012278

Reference yield:

: 1143521-44-1
N-methoxy-N-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxamide

: 1143521-06-5
(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0 - 20 °C

2.1: titanium(IV) isopropylate / tetrahydrofuran / 35 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

With titanium(IV) isopropylate; In tetrahydrofuran; 1.1: Gringnard reaction;
DOI:10.1021/jm9012278

Reference yield:

: 1143521-43-0
1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylic acid

: 1143521-06-5
(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: titanium(IV) isopropylate / tetrahydrofuran / 35 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

With titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; 2.1: Gringnard reaction;
DOI:10.1021/jm9012278