4-METHOXYPHENYLPHOSPHONIC ACID DIETHYL ESTER

Base Information

• Chemical Name: 4-METHOXYPHENYLPHOSPHONIC ACID DIETHYL ESTER
• CAS No.: 3762-33-2
• Molecular Formula: C11H17 O4 P
• Molecular Weight: 244.227
• Hs Code.: 2931900090
• Mol file: 3762-33-2.mol

Synonyms:Phosphonicacid, (4-methoxyphenyl)-, diethyl ester (9CI); Phosphonic acid,(p-methoxyphenyl)-, diethyl ester (7CI,8CI); Diethyl(p-methoxyphenyl)phosphonate; Diethyl 4-methoxyphenylphosphonate; Diethylp-anisylphosphonate

Chemical Property of 4-METHOXYPHENYLPHOSPHONIC ACID DIETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000554mmHg at 25°C
• Melting Point: 159-161°C
• Refractive Index: 1.483
• Boiling Point: 321.6°C at 760 mmHg
• Flash Point: 162.1°C
• PSA: 54.57000
• Density: 1.12g/cm³
• LogP: 2.58660

Purity/Quality:

99% ^*data from raw suppliers

Diethyl 4-Methoxyphenylphosphonate ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXYPHENYLPHOSPHONIC ACID DIETHYL ESTER

There total 53 articles about 4-METHOXYPHENYLPHOSPHONIC ACID DIETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(4-methoxyphenyl)phosphonic acid (21778-19-8) + Triethyl orthoacetate (78-39-7) → diethyl (p-methoxyphenyl)phosphonate (3762-33-2)

Guidance literature:

at 90 ℃; for 24h; Green chemistry;

DOI:10.3390/molecules26185637

Reference yield: 96.0%

para-iodoanisole (696-62-8) + phosphonic acid diethyl ester (762-04-9) → diethyl (p-methoxyphenyl)phosphonate (3762-33-2)

Guidance literature:

With triethylsilane; bis-triphenylphosphine-palladium(II) chloride; triethylamine; In toluene; for 0.15h; Irradiation;

DOI:10.1080/10426509708033697

Reference yield: 95.0%

1-bromo-4-methoxy-benzene (104-92-7) + phosphonic acid diethyl ester (762-04-9) → diethyl (p-methoxyphenyl)phosphonate (3762-33-2)

Guidance literature:

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 90 ℃; for 17h;

DOI:10.1055/s-1981-29335

upstream raw materials:

para-iodoanisole

triethyl phosphite

pinacolone enolate anion

diethyl phosphite

Downstream raw materials:

(4-methoxyphenyl)phosphonic acid

4-methoxyphenylphosphonic dichloride

4-methoxylphenyl phosphonic acid monoethyl ester

(4-methoxyphenyl)chlorophosphonic acid ethyl ester

Refernces

• 1、 Farrokhi, Alireza,Rouzifar, Majid,Sansano, José Miguel,Sobhani, Sara. "Fe-MIL-101 modified by isatin-Schiff-base-Co: a heterogeneous catalyst for C-C, C-O, C-N, and C-P cross coupling reactions". . p. 19963 - 19976. Retrieved 2021/11/12.
• 2、 Zhu, Da-Liang,Jiang, Shan,Wu, Qi,Wang, Hao,Chai, Lu-Lu,Li, Hai-Yan,Li, Hong-Xi. "Visible-Light-Induced Nickel-Catalyzed P(O)-C(sp2) Coupling Using Thioxanthen-9-one as a Photoredox Catalysis". supporting information. p. 160 - 165. Retrieved 2021/01/09.