DL-METHIONINE-D3

Base Information

• Chemical Name: DL-METHIONINE-D3
• CAS No.: 284665-20-9
• Molecular Formula: C₅H₁₁NO₂S
• Molecular Weight: 153.179
• Mol file: 284665-20-9.mol

Synonyms:DL-METHIONINE-D3;DL-METHIONINE-D3 (S-METHYL-D3)

Chemical Property of DL-METHIONINE-D3

Chemical Property:

• Melting Point: 280 °C (dec.)(lit.)
• PSA: 88.62000
• LogP: 0.85170
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Methionine-methyl-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methionine-methyl-d3 is the labeled Methionine-methyl, a useful building block.

Technology Process of DL-METHIONINE-D3

There total 12 articles about DL-METHIONINE-D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

iodomethane-d3 (865-50-9) + DL-homocysteine thiolactone hydrochloride (18265-50-4) → DL-methionine-methyl-2H3 (13010-53-2,284665-18-5,284665-20-9)

Guidance literature:

With sodium hydroxide; In ethanol; 1) room temp.; 2) reflux, 1 h;

DOI:10.1021/jo00194a014

Reference yield: 75.0%

C11H18(2)H3NO4S → L-2H3>methionine (13010-53-2,284665-18-5,284665-20-9)

Guidance literature:

With sulfuric acid; Reflux;

Reference yield: 64.0%

C7H6(2)H7NO3S (331665-06-6) → L-[3,3,4,4,S-methyl-2H7]methionine (284665-18-5,284665-20-9) + C7H6(2)H7NO3S

Guidance literature:

With porcine kidney acylase; In water; at 37 ℃; for 48h; pH=7.8;

DOI:10.1002/jlcr.428

upstream raw materials:

L-homocystine

[13C₂H₃] methyl iodide

iodomethane-d3

DL-homocysteine thiolactone hydrochloride

Downstream raw materials:

22-dihydrochondrillasterol

22-dihydro-25-dehydrochondrillasterol

Refernces

• 1、 -. "Synthetic method of stable isotope deuterium-labeled alpha-amino acid". Paragraph 0096; 0100-0101. . Retrieved 2019/12/15.
• 2、 Hasegawa, Hiroshi,Shinohara, Yoshihiko,Tagoku, Kazunori,Hashimoto, Takao. "Synthesis of L-[3,3,4,4,S-methyl-2H7]methionine for use as a substrate for the methionine loading test". . p. 21 - 30. Retrieved 2007/10/03.