Technology Process of geranylgeranyl acetate
There total 1 articles about geranylgeranyl acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 3 steps
1: 1) lithium biphenylide, barium iodide / 1) THF, -78 deg C, 30 min, 2) THF, a) -78 deg C, 1.5 h, b) room temperature, 16 h
2: 95 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 16 h / 23 °C
3: 100 percent / pyridine / 3 h / 23 °C
With
pyridine; lithium biphenylide; barium(II) iodide; tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(00)79008-3
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 63 percent / 1.8 N HCl in pentane / pentane / 0.08 h / -78 °C
2: azoisobutyronitrile, tributyltin hydride / cyclohexane / 1 h / 75 °C
With
hydrogenchloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
cyclohexane; pentane;
DOI:10.1016/S0040-4020(01)88050-9
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: mercury ditrifluoroacetate; N,N-dimethylaniline; MeNO2
1.2: KBr
1.3: NaOH; NaBH4 / ethanol; CH2Cl2; H2O
2.1: 62 percent / 4-(dimethylamino)pyridine; triethylamine / CH2Cl2 / 3 h / 20 °C
3.1: 95 percent / 4-(dimethylamino)pyridine; N,N-diisopropylethylamine / CH2Cl2 / 21 h / 50 - 70 °C
4.1: 96 percent / tetrabutylammonium fkuoride / tetrahydrofuran / 21 h / 60 - 70 °C
5.1: PCC; CH3COONa / CH2Cl2 / 4.5 h / 0 °C
6.1: tert-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
6.2: 65 percent / tetrahydrofuran / 3 h / -78 °C
7.1: H2 / Pd(OH)2/C / ethanol; ethyl acetate / 20 °C
7.2: O2 / ethanol; ethyl acetate
With
dmap; nitromethane; hydrogen; tert.-butyl lithium; sodium acetate; N,N-dimethyl-aniline; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate;
palladium dihydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/np060481l
