(R,S)-N-(3,4-dimethyl-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid benzyl ester

Base Information

Chemical Name:(R,S)-N-(3,4-dimethyl-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid benzyl ester
CAS No.:1111735-72-8
Molecular Formula:C₃₃H₃₀F₃NO₃
Molecular Weight:545.601
Hs Code.:

Synonyms:(R,S)-N-(3,4-dimethyl-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid benzyl ester

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Chemical Property of (R,S)-N-(3,4-dimethyl-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid benzyl ester

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Technology Process of (R,S)-N-(3,4-dimethyl-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid benzyl ester

There total 1 articles about (R,S)-N-(3,4-dimethyl-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1111734-75-8
3,4-dimethyl-N-(4-(trifluoromethyl)phenethyl)aniline

: 25774-02-1
monobenzyl phenylmalonate

: 1111735-72-8
(R,S)-N-(3,4-dimethyl-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid benzyl ester

Guidance literature:: monobenzyl phenylmalonate; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 0 ℃; for 2h;

3,4-dimethyl-N-(4-(trifluoromethyl)phenethyl)aniline; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 22h;

Reference yield: 78.0%

: 1111735-72-8
(R,S)-N-(3,4-dimethyl-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid benzyl ester

: 1111733-77-7
(R,S)-N-(3,4-Dimethyl-phenyl)-3-hydroxy-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-propionamide

Guidance literature:: (R,S)-N-(3,4-dimethyl-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid benzyl ester; With sodium tetrahydroborate; calcium chloride; In methanol; at 0 - 20 ℃; for 7.5h;

With hydrogenchloride; water; In methanol;