N2,N2-DIMETHYL-3-(TRIFLUOROMETHYL)PYRIDINE-2,5-DIAMINE

Base Information

• Chemical Name: N2,N2-DIMETHYL-3-(TRIFLUOROMETHYL)PYRIDINE-2,5-DIAMINE
• CAS No.: 288247-16-5
• Molecular Formula: C₈H₁₀F₃N₃
• Molecular Weight: 205.183
• Hs Code.: 2933399990
• Mol file: 288247-16-5.mol

Synonyms:N₂,N₂-dimethyl-3-(trifluoromethyl)pyridine-2,5-diamine

Chemical Property of N2,N2-DIMETHYL-3-(TRIFLUOROMETHYL)PYRIDINE-2,5-DIAMINE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N2,N2-Dimethyl-3-(trifluoromethyl)pyridine-2,5-diamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T

MSDS Files:

Useful:

Technology Process of N2,N2-DIMETHYL-3-(TRIFLUOROMETHYL)PYRIDINE-2,5-DIAMINE

There total 4 articles about N2,N2-DIMETHYL-3-(TRIFLUOROMETHYL)PYRIDINE-2,5-DIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

N,N-dimethyl-5-nitro-3-(trifluoromethyl)pyridin-2-amine (813425-49-9) → N2,N2-dimethyl-3-(trifluoromethyl)pyridine-2,5-diamine (288247-16-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 1h;

Reference yield:

2-chloro-3-iodo-5-nitropyridine (25391-60-0) → N2,N2-dimethyl-3-(trifluoromethyl)pyridine-2,5-diamine (288247-16-5)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; hydrogen / N,N-dimethyl-formamide / 19 h / 70 °C

2: 18-crown-6 ether; potassium carbonate / acetonitrile / 12 h / Reflux

3: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

With copper(l) iodide; 18-crown-6 ether; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

2-chloro-5-nitro-3-(trifluoromethyl)pyridine (99368-67-9) → N2,N2-dimethyl-3-(trifluoromethyl)pyridine-2,5-diamine (288247-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 18-crown-6 ether; potassium carbonate / acetonitrile / 12 h / Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

With 18-crown-6 ether; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; acetonitrile;

upstream raw materials:

2-chloro-3-iodo-5-nitropyridine

2-chloro-5-nitro-3-(trifluoromethyl)pyridine

N,N-dimethyl-5-nitro-3-(trifluoromethyl)pyridin-2-amine

Downstream raw materials:

phenyl 6-(dimethylamino)-5-(trifluoromethyl)pyridin-3-ylcarbamate

1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(dimethylamino)-5-(trifluoromethyl)pyridin-3-yl)urea

1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(dimethylamino)-5-(trifluoromethyl)pyridin-3-yl)urea

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