3-(2-Hydroxymethyl-4,6-dimethoxy-phenylethynyl)-2,2,4-trimethyl-cyclohex-3-enone

Base Information

Chemical Name:3-(2-Hydroxymethyl-4,6-dimethoxy-phenylethynyl)-2,2,4-trimethyl-cyclohex-3-enone
CAS No.:173044-49-0
Molecular Formula:C₂₀H₂₄O₄
Molecular Weight:328.408
Hs Code.:

Synonyms:3-(2-Hydroxymethyl-4,6-dimethoxy-phenylethynyl)-2,2,4-trimethyl-cyclohex-3-enone

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Chemical Property of 3-(2-Hydroxymethyl-4,6-dimethoxy-phenylethynyl)-2,2,4-trimethyl-cyclohex-3-enone

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Technology Process of 3-(2-Hydroxymethyl-4,6-dimethoxy-phenylethynyl)-2,2,4-trimethyl-cyclohex-3-enone

There total 7 articles about 3-(2-Hydroxymethyl-4,6-dimethoxy-phenylethynyl)-2,2,4-trimethyl-cyclohex-3-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 173044-52-5
Acetic acid 3,5-dimethoxy-2-(2,6,6-trimethyl-5-oxo-cyclohex-1-enylethynyl)-benzyl ester

: 173044-49-0
3-(2-Hydroxymethyl-4,6-dimethoxy-phenylethynyl)-2,2,4-trimethyl-cyclohex-3-enone

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; water; for 5h; Ambient temperature;
DOI:10.1021/jo951935e

Reference yield:

: 705-76-0
3,5-dimethoxybenzyl alcohol

: 173044-49-0
3-(2-Hydroxymethyl-4,6-dimethoxy-phenylethynyl)-2,2,4-trimethyl-cyclohex-3-enone

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / pyridine / CH₂Cl₂

2: 94 percent / iodine, acetic acid, aq. H₂O₂ / 6.5 h

3: 85 percent / Et₃N, Pd(OAc)2, PPh₃ / 3.5 h / Heating

4: 80 percent / pyridine, POCl₃ / benzene / 18 h / Ambient temperature

5: 91 percent / KOH / tetrahydrofuran; methanol; H₂O / 5 h / Ambient temperature

With pyridine; palladium diacetate; potassium hydroxide; dihydrogen peroxide; iodine; acetic acid; triethylamine; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; benzene;
DOI:10.1021/jo951935e

Reference yield:

: 38513-65-4
3,5-dimethoxybenzyl acetate

: 173044-49-0
3-(2-Hydroxymethyl-4,6-dimethoxy-phenylethynyl)-2,2,4-trimethyl-cyclohex-3-enone

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / iodine, acetic acid, aq. H₂O₂ / 6.5 h

2: 85 percent / Et₃N, Pd(OAc)2, PPh₃ / 3.5 h / Heating

3: 80 percent / pyridine, POCl₃ / benzene / 18 h / Ambient temperature

4: 91 percent / KOH / tetrahydrofuran; methanol; H₂O / 5 h / Ambient temperature

With pyridine; palladium diacetate; potassium hydroxide; dihydrogen peroxide; iodine; acetic acid; triethylamine; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; methanol; water; benzene;
DOI:10.1021/jo951935e