<<3-(2S)-(4S)>-3-(2-Methyl-1-oxo-5-phenyl-pent-4-ene-4-(phenylmethyl))>-2-oxazolidinone

Base Information

• Chemical Name: <<3-(2S)-(4S)>-3-(2-Methyl-1-oxo-5-phenyl-pent-4-ene-4-(phenylmethyl))>-2-oxazolidinone
• CAS No.: 141423-26-9
• Molecular Formula: C₂₂H₂₃NO₃
• Molecular Weight: 349.43
• Mol file: 141423-26-9.mol

Synonyms:<<3-(2S)-(4S)>-3-(2-Methyl-1-oxo-5-phenyl-pent-4-ene-4-(phenylmethyl))>-2-oxazolidinone

Chemical Property of <<3-(2S)-(4S)>-3-(2-Methyl-1-oxo-5-phenyl-pent-4-ene-4-(phenylmethyl))>-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <<3-(2S)-(4S)>-3-(2-Methyl-1-oxo-5-phenyl-pent-4-ene-4-(phenylmethyl))>-2-oxazolidinone

There total 6 articles about <<3-(2S)-(4S)>-3-(2-Methyl-1-oxo-5-phenyl-pent-4-ene-4-(phenylmethyl))>-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(S)-4-benzyl-3-propionyl-2-oxazolidinone (131685-53-5,101711-78-8) + 3-bromo-1-phenyl-1-propenyl bromide (4392-24-9) → (S)-4-benzyl-3-((R,E)-2-methyl-5-phenylpent-4-enoyl)oxazolidin-2-one (141423-26-9)

Guidance literature:

(S)-4-benzyl-3-propionyl-2-oxazolidinone; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

3-bromo-1-phenyl-1-propenyl bromide; In tetrahydrofuran; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c8cc01563e

Reference yield: 68.0%

(S)-4-benzyl-3-propionyl-2-oxazolidinone (131685-53-5,101711-78-8) + Cinnamyl bromide (4392-24-9) → (S)-4-benzyl-3-((R,E)-2-methyl-5-phenylpent-4-enoyl)oxazolidin-2-one (141423-26-9)

Guidance literature:

(S)-4-benzyl-3-propionyl-2-oxazolidinone; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

Cinnamyl bromide; In tetrahydrofuran; at -78 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tet.2021.132118

Reference yield: 65.0%

(3R)-3-propionyl-4-benzyloxazolidin-2-one (101711-78-8,131685-53-5) + Cinnamyl bromide (4392-24-9) → <<3-(2S)-(4S)>-3-(2-Methyl-1-oxo-5-phenyl-pent-4-ene-4-(phenylmethyl))>-2-oxazolidinone (141423-26-9)

Guidance literature:

(3R)-3-propionyl-4-benzyloxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

Cinnamyl bromide; In tetrahydrofuran; at -78 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tet.2021.132118

upstream raw materials:

(R)-4-(phenylmethyl)-2-oxazolidinone

(3R)-3-propionyl-4-benzyloxazolidin-2-one

Cinnamyl bromide

(S)-4-benzyl-3-propionyl-2-oxazolidinone

Downstream raw materials:

(2R,4E)-2-Methyl-5-phenyl-pent-4-en-1-al

<<3-(2R,4R,5R,6R,8E),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-9-phenyl-8-nonenyl)-4-(phenylmethyl)>-2-oxazolidinone

<<3-(2R,4S,5S,6R,8E),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-9-phenyl-8-nonenyl)-4-(phenylmethyl)>-2-oxazolidinone

N-Benzyl-N-[2(R)-methyl-1-oxo-5-phenyl-4(E)-pentenyl]amine