N-(4-(3-chlorophenyl)-5-(3-fluorobenzoyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Base Information

Chemical Name:N-(4-(3-chlorophenyl)-5-(3-fluorobenzoyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
CAS No.:1391981-66-0
Molecular Formula:C₂₇H₂₁ClFNO₄S₂
Molecular Weight:542.051
Hs Code.:

Synonyms:N-(4-(3-chlorophenyl)-5-(3-fluorobenzoyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(3-chlorophenyl)-5-(3-fluorobenzoyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Technology Process of N-(4-(3-chlorophenyl)-5-(3-fluorobenzoyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

There total 12 articles about N-(4-(3-chlorophenyl)-5-(3-fluorobenzoyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1391982-00-5
N-(4-(3-chlorophenyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

: 1711-07-5
3-fluorobenzoyl chloride

: 1391981-66-0
N-(4-(3-chlorophenyl)-5-(3-fluorobenzoyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: With tin(IV) chloride; In dichloromethane; 1,2-dichloro-ethane; Reflux;
DOI:10.1016/j.bmc.2013.12.021

Reference yield:

: 473438-03-8
ethyl 2-amino-4-(3-chlorophenyl)-thiophene-3-carboxylate

: 1391981-66-0
N-(4-(3-chlorophenyl)-5-(3-fluorobenzoyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

3: tin(IV) chloride / dichloromethane; 1,2-dichloro-ethane / Reflux

With tin(IV) chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2013.12.021

Reference yield:

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 1391981-66-0
N-(4-(3-chlorophenyl)-5-(3-fluorobenzoyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / Inert atmosphere; Reflux

2: tin(IV) chloride / dichloromethane; 1,2-dichloro-ethane / Reflux

With tin(IV) chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2013.12.021