(4R,5S,6S,7R)-4,7-dibenzyl-5,6-O-isopropylidene-1,3,2-dioxathiepane 2,2-dioxide

Base Information

Chemical Name:(4R,5S,6S,7R)-4,7-dibenzyl-5,6-O-isopropylidene-1,3,2-dioxathiepane 2,2-dioxide
CAS No.:495385-02-9
Molecular Formula:C₂₁H₂₄O₆S
Molecular Weight:404.484
Hs Code.:

Synonyms:(4R,5S,6S,7R)-4,7-dibenzyl-5,6-O-isopropylidene-1,3,2-dioxathiepane 2,2-dioxide

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Chemical Property of (4R,5S,6S,7R)-4,7-dibenzyl-5,6-O-isopropylidene-1,3,2-dioxathiepane 2,2-dioxide

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Technology Process of (4R,5S,6S,7R)-4,7-dibenzyl-5,6-O-isopropylidene-1,3,2-dioxathiepane 2,2-dioxide

There total 1 articles about (4R,5S,6S,7R)-4,7-dibenzyl-5,6-O-isopropylidene-1,3,2-dioxathiepane 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.2%

: 136740-96-0
(2R,3R,4R,5R)-3,4-O-isopropylidene-1,6-diphenyl-2,3,4,5-hexanetetraol

: 495385-02-9
(4R,5S,6S,7R)-4,7-dibenzyl-5,6-O-isopropylidene-1,3,2-dioxathiepane 2,2-dioxide

Guidance literature:: (2R,3R,4R,5R)-3,4-O-isopropylidene-1,6-diphenyl-2,3,4,5-hexanetetraol; With pyridine; thionyl chloride; In dichloromethane; at 20 ℃; for 3h;

With ruthenium trichloride; sodium periodate; In dichloromethane; water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1002/1099-0682(200210)2002:10<2614::AID-EJIC2614>3.0.CO;2-2

Reference yield: 54.6%

: 80510-04-9
1,2-bis(phosphino)benzene

: 495385-02-9
(4R,5S,6S,7R)-4,7-dibenzyl-5,6-O-isopropylidene-1,3,2-dioxathiepane 2,2-dioxide

: 495385-05-2
1,2-bis[(2S,3S,4S,5S)-2,5-dibenzyl-3,4-O-isopropylidenephospholanyl]benzene

Guidance literature:: 1,2-bis(phosphino)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 2h;

(4R,5S,6S,7R)-4,7-dibenzyl-5,6-O-isopropylidene-1,3,2-dioxathiepane 2,2-dioxide; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 16h;
DOI:10.1002/1099-0682(200210)2002:10<2614::AID-EJIC2614>3.0.CO;2-2

Reference yield:

: 495385-02-9
(4R,5S,6S,7R)-4,7-dibenzyl-5,6-O-isopropylidene-1,3,2-dioxathiepane 2,2-dioxide

: 495385-08-5
1,2-bis[(2S,3S,4S,5S)-2,5-dibenzyl-3,4-dihydroxyphospholanyl]benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBuLi / hexane; tetrahydrofuran / 2 h / 20 °C

1.2: 54.6 percent / nBuLi / tetrahydrofuran; hexane / 16 h / 20 °C

2.1: 56.9 percent / CH₃SO₃H / H₂O; methanol / 2.5 h / Heating

With n-butyllithium; methanesulfonic acid; In tetrahydrofuran; methanol; hexane; water;
DOI:10.1002/1099-0682(200210)2002:10<2614::AID-EJIC2614>3.0.CO;2-2