C₂₁H₁₃F₆NO₂

Base Information

• Chemical Name: C₂₁H₁₃F₆NO₂
• CAS No.: 1416860-94-0
• Molecular Formula: C₂₁H₁₃F₆NO₂
• Molecular Weight: 425.33
• Mol file: 1416860-94-0.mol

Synonyms:C₂₁H₁₃F₆NO₂

Chemical Property of C₂₁H₁₃F₆NO₂

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₂₁H₁₃F₆NO₂

There total 8 articles about C₂₁H₁₃F₆NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.6%

6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-ol (1416860-92-8) + 1-(bromomethyl)-2,4-difluorobenzene (23915-07-3) → C21H13F6NO2 (1416860-94-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 5h;

Reference yield:

2,4-difluorobenzaldehyde (1550-35-2) → C21H13F6NO2 (1416860-94-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate; methanol / 1 h / 0 °C

2: phosphorus tribromide / diethyl ether / 2 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 - 70 °C

With methanol; sodium tetrahydroborate; phosphorus tribromide; potassium carbonate; In diethyl ether; N,N-dimethyl-formamide;

Reference yield:

2,5-dibromopyridine (624-28-2) → C21H13F6NO2 (1416860-94-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / 0.25 h / -70 °C

2.2: 2 h / -70 - 20 °C

3.1: diethyl ether / 2 h / 0 - 20 °C

4.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C

4.2: 0.67 h / -78 - 20 °C

5.1: Oxone / water; acetone / 18 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 - 70 °C

With Oxone; n-butyllithium; copper; potassium carbonate; In diethyl ether; hexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

upstream raw materials:

2,4-difluorobenzaldehyde

6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-ol

1-(bromomethyl)-2,4-difluorobenzene

2,5-dibromopyridine

Refernces